Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2019-000266
Abstract: Background The use of checkpoint inhibitors has revolutionized cancer therapy. Unfortunately, these therapies often cause immune-related adverse effects, largely due to a lack of tumor specificity. Methods We stained human natural killer cells using fusion… read more here.
Keywords: tumor specificity; nectin4 novel; checkpoint; ligand ... See more keywords
Quantitative Structure–Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones
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DOI: 10.21873/anticanres.13862
Abstract: Background/Aim: 4H-1-Benzopyran-4-one (chromone), present in various flavonoids as a backbone structure, has been used for the synthesis of anticancer drugs. The study aimed at investigating the cytotoxicity of eight 2-arylazolylchromones and twelve 2-triazolylchromones against four… read more here.
Keywords: tumor specificity; quantitative structure; structure cytotoxicity; structure ... See more keywords
Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives
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DOI: 10.3390/ijms23052601
Abstract: Background: Very few papers covering the anticancer activity of azulenes have been reported, as compared with those of antibacterial and anti-inflammatory activity. This led us to investigate the antitumor potential of fifteen 4,6,8-trimethyl azulene amide… read more here.
Keywords: trimethyl azulene; amide derivatives; activity; tumor specificity ... See more keywords