Biomaterials-Based Approaches to Tumor Spheroid and Organoid Modeling.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201700980
Abstract: Evolving understanding of structural and biological complexity of tumors has stimulated development of physiologically relevant tumor models for cancer research and drug discovery. A major motivation for developing new tumor models is to recreate the… read more here.
Keywords: approaches tumor; tumor spheroid; biomaterials based; based approaches ... See more keywords
Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119547
Abstract: Tumor vasculature creates a hostile tumor microenvironment (TME) in vivo and nourishes cancers, resulting in cancer progression and drug resistance. To mimic the biochemical and biomechanical environments of tumors in vitro, several models integrated with… read more here.
Keywords: drug; tumor spheroid; vascular network; tumor ... See more keywords
Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00257
Abstract: The extracellular matrix (ECM) plays an important regulatory role in the development and progression of tumoral tissue. Its functions and properties are crucial in determining tumor cell behavior such as invasion, migration, and malignancy development.… read more here.
Keywords: laponite nanoclay; collagen; spheroid growth; tumor spheroid ... See more keywords
Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation
Sign Up to like & getrecommendations! Published in 2021 at "Biomedical Optics Express"
DOI: 10.1364/boe.440444
Abstract: We present a completely label-free three-dimensional (3D) optical coherence tomography (OCT)-based tissue dynamics imaging method for visualization and quantification of the metabolic and necrotic activities of tumor spheroid. Our method is based on a custom… read more here.
Keywords: three dimensional; optical coherence; tumor spheroid; coherence tomography ... See more keywords
Evaluation of AMG510 Therapy on KRAS-Mutant Non–Small Cell Lung Cancer and Colorectal Cancer Cell Using a 3D Invasive Tumor Spheroid System under Normoxia and Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9120792
Abstract: A 3D tumor spheroid has been increasingly applied in pharmaceutical development for its simulation of the tumor structure and microenvironment. The embedded-culture of a tumor spheroid within a hydrogel microenvironment could help to improve the… read more here.
Keywords: cell; cancer; tumor spheroid; methodology ... See more keywords
High-Throughput 3D Tumor Spheroid Array Platform for Evaluating Sensitivity of Proton-Drug Combinations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020587
Abstract: Proton beam therapy (PBT) is a critical treatment modality for head and neck squamous cell carcinoma (HNSCC). However, not much is known about drug combinations that may improve the efficacy of PBT. This study aimed… read more here.
Keywords: drug combinations; hnscc; tumor spheroid; array platform ... See more keywords