New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202201784
Abstract: Previous studies have developed vascularized tumor spheroid models to demonstrate the impact of intravascular flow on tumor progression and treatment. However, these models have not been widely adopted so the vascularization of tumor spheroids in… read more here.
Keywords: new strategy; vascularization; tumor spheroids; tumor ... See more keywords
Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201702858
Abstract: Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano-biotechnology field as they can provide easily accessible… read more here.
Keywords: tumor; mcts vitro; tool; multicellular tumor ... See more keywords
Bioinstructive microparticles for self-assembly of mesenchymal stem Cell-3D tumor spheroids.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.09.007
Abstract: 3D multicellular tumor spheroids (3D-MCTS) that closely mimic in vitro the complex lung tumor microenvironment (TME) are highly desirable for screening innovative anti-cancer therapeutics. Despite significant improvements in mimicking lung TME, few models have combined… read more here.
Keywords: tumor; tumor spheroids; hbm mscs; cell ... See more keywords
Integrative In Situ Photodynamic Therapy-Induced Cell Death Measurement of 3D-Bioprinted MCF-7 Tumor Spheroids.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03022
Abstract: The development of new in vitro models that closely mimic the tumor microenvironment (TME) to evaluate the efficacy of anticancer drugs has received great attention. In this study, a three-dimensional (3D) bioprinted Michigan Cancer Foundation-7… read more here.
Keywords: integrative situ; spheroid; tumor spheroids; photodynamic therapy ... See more keywords
Exploring the photo-toxicity of hypoxic active iridium(III)-based sensitizers in 3D tumor spheroids.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b07723
Abstract: Among all molecules developed for anticancer therapies, photodynamic therapeutic agents have a unique profile. Their maximal activity is specifically triggered in tumors by light and toxicity of even systemically delivered drug is prevented in non-illuminated… read more here.
Keywords: oxygen; toxicity; tumor spheroids; iii based ... See more keywords
Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35216-7
Abstract: Even though in vitro co-culture tumor spheroid model plays an important role in screening drug candidates, its wide applications are currently limited due to the lack of reliable and high throughput methods for generating well-defined… read more here.
Keywords: uniform sized; multicellular tumor; tumor spheroids; sized multicellular ... See more keywords
Engineering orthotopic tumor spheroids with organ-specific vasculatures for local chemoembolization evaluation.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01632j
Abstract: Developing a three-dimensional (3D) in vitro tumor model with vasculature systems suitable for testing endovascular interventional therapies remains a challenge. Here we develop an orthotopic liver tumor spheroid model that captures the organ-level complexity of… read more here.
Keywords: organ specific; orthotopic tumor; specific vasculatures; tumor spheroids ... See more keywords
Magnetic molding of tumor spheroids: emerging model for cancer screening.
Sign Up to like & getrecommendations! Published in 2020 at "Biofabrication"
DOI: 10.1088/1758-5090/abc670
Abstract: Three-dimensional tissue culture, and particularly spheroid models, have recently been recognized as highly relevant in drug screening, toxicity assessment and tissue engineering due to their superior complexity and heterogeneity akin to the in vivo microenvironment.… read more here.
Keywords: magnetic molding; tumor spheroids; cancer; cell ... See more keywords
Abstract 1400: Using tumor spheroids to evaluate the efficacy of EZH2 inhibitors in clear cell renal cell carcinoma (ccRCC)
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1400
Abstract: Enhancer of zeste homolog 2 (EZH2) is a key component of the polycomb repressive complex 2 (PRC2). EZH2 is frequently overexpressed in a wide variety of human malignancies including non-Hodgkin lymphoma, gastric cancer, pancreatic cancer,… read more here.
Keywords: swi snf; cell; ccrcc; tumor spheroids ... See more keywords
Abstract 332: Simultaneous inhibition of EZH2 and activation of dopamine D1 in an isotropic triple-negative breast cancer microgel model
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-332
Abstract: Triple negative breast cancer (TNBC) cells overexpress enhancer of zeste homolog 2 (EZH2) the catalytic subunit of polycomb repressive complex 2 (PRC2). EZH2 is a potential driver of TNBC metastasis, and its high expression strongly… read more here.
Keywords: growth; breast cancer; tumor spheroids; tumor ... See more keywords
Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3319-0
Abstract: BackgroundMulticellular Tumor Spheroids are frequently used to mimic the regionalization of proliferation and the hypoxic environment within avascular tumors. Here we exploit these features to study the activation of DNA damage repair pathways and their… read more here.
Keywords: proliferation; dna damage; tumor spheroids; damage ... See more keywords