Multiperspective quantitative tumor-stroma ratio reveals histological areas associated with poor outcomes in oral squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5909
Abstract: AIMS Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological characteristics, and the individual histological characteristics of the tumors are poorly understood. Therefore, calculating the proportion of tumor cells in different regions that… read more here.
Keywords: inner tumor; cell carcinoma; squamous cell; oral squamous ... See more keywords
The prognostic value of tumor–stroma ratio in tumor‐positive axillary lymph nodes of breast cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31658
Abstract: The tumor–stroma ratio (TSR) has previously been found to be a strong prognostic parameter in primary breast cancer tumors. Since the presence of tumor cells in lymph nodes is important for clinical decision making, the… read more here.
Keywords: tumor positive; lymph nodes; lymph; cancer ... See more keywords
Associations Between ADC and Tumor Infiltrating Lmphocytes, Tumor-Stroma Ratio and Vimentin Expression in Head and Neck Squamous Cell Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Academic radiology"
DOI: 10.1016/j.acra.2021.05.007
Abstract: RATIONALE AND OBJECTIVES The present study used diffusion-weighted imaging (DWI) to elucidate possible associations with tumor-infiltrating lymphocytes (TIL), tumor-stroma ratio and vimentin expression in head and neck squamous cell cancer (HNSCC). MATERIALS AND METHODS 30… read more here.
Keywords: stroma ratio; vimentin expression; expression; tumor stroma ... See more keywords
Microphysiological systems to study tumor-stroma interactions in brain cancer
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.06.012
Abstract: Brain tumors still lack effective treatments, and the mechanisms of tumor progression and therapeutic resistance are unclear. Multiple parameters affect cancer prognosis (e.g., type and grade, age, location, size, and genetic mutations) and election of… read more here.
Keywords: cancer; tumor stroma; brain; stroma interactions ... See more keywords
Reprogramming tumor stroma using an endogenous lipid lipoxin A4 to treat pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.01.072
Abstract: Pancreatic stellate cells (PSCs) are the precursors of cancer-associated fibroblasts (CAFs), which potentiate pancreatic tumor growth and progression. In this study, we investigated whether Lipoxin A4 (LXA4), an endogenous bioactive lipid, can inhibit the differentiation… read more here.
Keywords: pancreatic cancer; hpscs; cancer; treat pancreatic ... See more keywords
18F-fluorodeoxyglucose uptake in advanced gastric cancer correlates with histopathological subtypes and volume of tumor stroma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2021.110048
Abstract: PURPOSE The aim of this study was to investigate the correlation between preoperative 18F-fluorodeoxyglucose (FDG) uptake and histological subtypes, amount of tumor stroma in advanced gastric cancer (GC), and clinical outcomes. METHODS We evaluated 56… read more here.
Keywords: cd34; uptake; tlr; suvmax ... See more keywords
Therapeutic Targeting of the Colorectal Tumor Stroma.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.09.045
Abstract: Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, which all affect the tumor microenvironment (TME). Elements of the TME serve as therapeutic targets and might be used as… read more here.
Keywords: colorectal tumor; therapeutic targeting; targeting colorectal; tumor stroma ... See more keywords
The Relationship Between Tumor-Stroma Ratio, the Immune Microenvironment, and Survival in Patients With Spinal Chordoma.
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgery"
DOI: 10.1093/neuros/nyz333
Abstract: BACKGROUND Currently, little is known about the clinical relevance of tumor-stroma ratio (TSR) in chordoma and data discussing the relationship between TSR and immune status of chordoma are lacking. OBJECTIVE To characterize TSR distribution in… read more here.
Keywords: stroma ratio; tsr; tumor stroma; chordoma ... See more keywords
Value of the Tumor Stroma Ratio and Structural Heterogeneity Measured by a Novel Semi-Automatic Image Analysis Technique for Predicting Survival in Patients with Colon Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Diseases of the colon and rectum"
DOI: 10.1097/dcr.0000000000002570
Abstract: BACKGROUND The tumor stroma ratio and intratumor stromal heterogeneity have been identified as prognostic factors for several carcinomas. Recent advancements in image analysis technologies and their application to medicine have enable detailed analysis of clinical… read more here.
Keywords: stroma ratio; heterogeneity; tumor stroma; intratumor stromal ... See more keywords
Vimentin and tumor–stroma ratio for neoadjuvant chemoradiotherapy response prediction in locally advanced rectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15610
Abstract: Vimentin expression in tumor tissues and the tumor–stroma ratio (TSR) have been demonstrated as strong prognostic factors for cancer patients, but whether they are predictive markers of neoadjuvant chemoradiotherapy (nCRT) outcome in locally advanced rectal… read more here.
Keywords: vimentin; tsr; vimentin tsr; response ... See more keywords
The secret(ing) life of the tumor stroma
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.363.6427.594-u
Abstract: Cancer Hypoxic solid tumors develop a dysfunctional vasculature that prevents efficient chemotherapeutic penetration. Kugeratski et al. analyzed the proteome and secretome of cancer-associated fibroblasts, a prominent cell type in the tumor stroma. Hypoxia increased the… read more here.
Keywords: ing life; secret ing; cancer; tumor ... See more keywords