Cystatin M/E (Cystatin 6): A Janus-Faced Cysteine Protease Inhibitor with Both Tumor-Suppressing and Tumor-Promoting Functions
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DOI: 10.3390/cancers13081877
Abstract: Simple Summary Cystatin M/E is a low molecular mass protein and a potent inhibitor of proteolytic enzymes (cathepsins B, L, V, and legumain). Cystatin M/E participates in epidermal homeostasis and its deregulation is associated with… read more here.
Keywords: inhibitor; tumor suppressing; cystatin; cancer ... See more keywords
The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs)
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DOI: 10.3390/proteomes11010005
Abstract: Unlike a prevalent expectation that tumor cells secrete tumor-promoting proteins and stimulate the progression of neighboring tumor cells, accumulating evidence indicates that the role of tumor-secreted proteins is double-edged and context-dependent. Some of the oncogenic… read more here.
Keywords: tumor cells; tumor secreted; tumor suppressing; secrete tumor ... See more keywords
Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs)
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DOI: 10.7150/ijbs.79155
Abstract: Induced tumor-suppressing cells (iTSCs) can be generated from cancer and non-cancer cells. Here, three paradoxical maxims for the action of iTSCs are reviewed: the secretion of tumor-suppressing proteins, their role as a “double-edged” sword, and… read more here.
Keywords: suppressing cells; cancer; tumor suppressing; cancer cells ... See more keywords