Systemic Tumor Suppression via Macrophage-Driven Automated Homing of Metal-Phenolic-Gated Nanosponges for Metastatic Melanoma.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207488
Abstract: Cell-based therapies comprising the administration of living cells to patients for direct therapeutic activities have experienced remarkable success in the clinic, of which macrophages hold great potential for targeted drug delivery due to their inherent… read more here.
Keywords: suppression via; systemic tumor; tumor suppression; tumor ... See more keywords
Osthole interacts with an ER‐mitochondria axis and facilitates tumor suppression in ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29913
Abstract: Osthole is a natural coumarin found in a variety of plants and has been reported to have diverse biological functions, including antimicrobial, antiviral, immunomodulatory, and anticancer effects. Here, we investigated the natural derivative osthole as… read more here.
Keywords: cancer; tumor suppression; ovarian cancer; suppression ovarian ... See more keywords
Deciphering p53 signaling in tumor suppression.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2017.11.005
Abstract: The p53 transcription factor is mutated in over half of human cancers, and p53-null mice are highly predisposed to cancer, highlighting p53s essential role in tumor suppression. Studies in mouse models have revealed that p53… read more here.
Keywords: deciphering p53; tumor suppression; p53; cell ... See more keywords
Entirely Synthetic Bacterial Nanomimics for Highly-Effective Tumor Suppression and Immune Elicitation
Sign Up to like & getrecommendations! Published in 2020 at "Nano Today"
DOI: 10.1016/j.nantod.2020.100950
Abstract: ABSTRACT Bacteria are considered to be “perfect” anticancer agents on account of their unique capabilities of specific tumor targeting, active intratumoral penetration and controllable cytotoxicity induction, but so far there is no great success in… read more here.
Keywords: synthetic bacterial; entirely synthetic; bnms; tumor suppression ... See more keywords
p53 and Tumor Suppression: It Takes a Network.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.12.011
Abstract: The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53 suppresses tumorigenesis by transcriptionally regulating a network of target genes that play roles in various cellular processes. Though originally characterized as… read more here.
Keywords: network; tumor suppression; biology; p53 ... See more keywords
Mitochondrial SO2-Activated NIR Photodiagnostic Agent Harnessing Hydroxyl Radicals for Efficient Inflammation Eradication and Tumor Suppression.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c06034
Abstract: At present, some progress has been made in developing NIR light-responsive free radical generators. However, the efficacy of theranostics continues to be hindered by tumor-associated inflammatory reactions. Hence, fulfilling the in situ release of free… read more here.
Keywords: inflammation eradication; tumor suppression; inflammation; eradication tumor ... See more keywords
Deconstructing networks of p53-mediated tumor suppression in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.171
Abstract: The transcription factor p53 is a vital tumor suppressor. Upon activation by diverse stresses including oncogene activation, DNA damage, hypoxia and nutrient deprivation, p53 activates a panoply of target genes and orchestrates numerous downstream responses… read more here.
Keywords: mediated tumor; p53 mediated; tumor suppression; p53 ... See more keywords
p53 in ferroptosis regulation: the new weapon for the old guardian.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00943-y
Abstract: Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. Among… read more here.
Keywords: ferroptosis; p53; p53 ferroptosis; cell death ... See more keywords
Ferroptosis as a new tool for tumor suppression through lipid peroxidation
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-07180-8
Abstract: As a newly defined type of programmed cell death, ferroptosis is considered a potent weapon against tumors due to its distinct mechanism from other types of programmed cell death. Ferroptosis is triggered by the uncontrolled… read more here.
Keywords: ferroptosis; lipid peroxidation; tumor suppression;
Minimally-invasive implantable device enhances brain cancer suppression
Sign Up to like & getrecommendations! Published in 2024 at "EMBO Molecular Medicine"
DOI: 10.1038/s44321-024-00091-5
Abstract: Current brain tumor treatments are limited by the skull and BBB, leading to poor prognosis and short survival for glioma patients. We introduce a novel minimally-invasive brain tumor suppression (MIBTS) device combining personalized intracranial electric… read more here.
Keywords: brain; tumor suppression; therapy; device ... See more keywords
Tumor suppression via diverting intracellular sialylation with multifunctional nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05598d
Abstract: Sialylation plays an important role in tumor-related physiological processes. Therefore, intervention of sialylation has great potential to explore new paths for tumor therapy. In view of the immune modulation of sialic acid (SA) on tumors,… read more here.
Keywords: intracellular sialylation; tumor suppression; suppression via; sialylation ... See more keywords