LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "tumor suppressive" as a keyword



A non‐canonical tumor suppressive role for the long non‐coding RNA MALAT1 in colon and breast cancers

Sign Up to like & get
recommendations! Published in 2018 at "International Journal of Cancer"

DOI: 10.1002/ijc.31386

Abstract: Long noncoding RNAs (lncRNAs) constitute one of the largest classes of transcripts and have been widely implicated in various diseases such as cancer. Increasing evidence suggests that several lncRNAs are dysregulated and play critical roles… read more here.

Keywords: colon breast; malat1; breast cancers; non canonical ... See more keywords

LncRNA NKILA correlates with the malignant status and serves as a tumor‐suppressive role in rectal cancer

Sign Up to like & get
recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.27300

Abstract: NF‐κB interacting lncRNA (NKILA) has been found to function as a tumor‐suppressive role in various human cancers. However, the role of NKILA in rectal cancer is still unknown. The objective of this study is to… read more here.

Keywords: lncrna nkila; rectal cancer; cancer; tumor suppressive ... See more keywords
Photo from archive.org

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma

Sign Up to like & get
recommendations! Published in 2019 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-019-03041-4

Abstract: Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the… read more here.

Keywords: 323a mir; mir 323a; mir 342; tumor suppressive ... See more keywords

Mendelian analysis reveals novel pancreatic cancer-associated gut bacteria with tumor-suppressive effects.

Sign Up to like & get
recommendations! Published in 2025 at "Cellular oncology"

DOI: 10.1007/s13402-025-01098-x

Abstract: The gut microbiota has been implicated in the development and progression of pancreatic cancer (PC), yet few specific bacterial species have been reported to exert functional effect on PC. This study aimed to identify novel… read more here.

Keywords: pancreatic cancer; analysis; suppressive effects; associated gut ... See more keywords

Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis.

Sign Up to like & get
recommendations! Published in 2021 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2021.114423

Abstract: Metastatic melanoma has a very high mortality rate despite the availability of chemotherapy, radiotherapy, and immunotherapy; therefore, more effective therapeutics are needed. The Hippo pathway plays an inhibitory role in melanoma progression, but the tumor… read more here.

Keywords: melanoma; melanoma cell; metastasis; hippo pathway ... See more keywords
Photo by nci from unsplash

Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium

Sign Up to like & get
recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.06.067

Abstract: SUMMARY Protein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings propelling… read more here.

Keywords: tumor suppressive; akt signaling; pi3k akt; pkc ... See more keywords
Photo by nci from unsplash

ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis

Sign Up to like & get
recommendations! Published in 2021 at "Oncogene"

DOI: 10.1038/s41388-021-01832-3

Abstract: ING2 (Inhibitor of Growth 2) is a tumor suppressor gene that has been implicated in critical biological functions (cell-cycle regulation, replicative senescence, DNA repair and DNA replication), most of which are recognized hallmarks of tumorigenesis… read more here.

Keywords: mitochondria involved; ing2 tumor; suppressive protein; ing2 ... See more keywords

6mer seed toxicity in tumor suppressive microRNAs

Sign Up to like & get
recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-06526-1

Abstract: Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine… read more here.

Keywords: seed; 6mer seed; toxicity; cancer cells ... See more keywords

Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p

Sign Up to like & get
recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-40857-3

Abstract: Gallbladder carcinoma (GBC) is a biliary tract cancer with few treatment options and poor prognosis. Radical surgery is the only potentially curative treatment option but most patients diagnosed with GBC are unresectable. Thus, there is… read more here.

Keywords: mir 145; gallbladder; activation stat1; gallbladder carcinoma ... See more keywords

miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2.

Sign Up to like & get
recommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"

DOI: 10.1093/abbs/gmaa159

Abstract: miR-195-5p has been widely explored in various cancers and is considered as a tumor-suppressive microRNA. However, its roles in human lung cancer pathogenesis are not fully elucidated. In this study, we aimed to explore how… read more here.

Keywords: overexpression; mir 195; trxr2; human lung ... See more keywords

MODL-09. IMAGE-BASED SCREENING IN MEDULLOBLASTOMA REVEALS TUMOR-SUPPRESSIVE EFFECTS OF THE NEUROPROTECTIVE AGENT URMC-12K

Sign Up to like & get
recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.753

Abstract: Abstract BACKGROUND Enhanced motility and the invasive behavior of medulloblastoma (MB) influence microenvironment interactions and may promote distant spread. Current drug screening focuses on cytotoxic agents, leaving subtle but potentially therapeutically relevant drug phenotypes associated… read more here.

Keywords: modl image; agent; urmc 12k; cell ... See more keywords