A non‐canonical tumor suppressive role for the long non‐coding RNA MALAT1 in colon and breast cancers
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31386
Abstract: Long noncoding RNAs (lncRNAs) constitute one of the largest classes of transcripts and have been widely implicated in various diseases such as cancer. Increasing evidence suggests that several lncRNAs are dysregulated and play critical roles… read more here.
Keywords: colon breast; malat1; breast cancers; non canonical ... See more keywords
LncRNA NKILA correlates with the malignant status and serves as a tumor‐suppressive role in rectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27300
Abstract: NF‐κB interacting lncRNA (NKILA) has been found to function as a tumor‐suppressive role in various human cancers. However, the role of NKILA in rectal cancer is still unknown. The objective of this study is to… read more here.
Keywords: lncrna nkila; rectal cancer; cancer; tumor suppressive ... See more keywords
Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03041-4
Abstract: Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic information. By contrast, the therapeutic potential of targeting the transcriptome, ~ 70% of the… read more here.
Keywords: 323a mir; mir 323a; mir 342; tumor suppressive ... See more keywords
Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114423
Abstract: Metastatic melanoma has a very high mortality rate despite the availability of chemotherapy, radiotherapy, and immunotherapy; therefore, more effective therapeutics are needed. The Hippo pathway plays an inhibitory role in melanoma progression, but the tumor… read more here.
Keywords: melanoma; melanoma cell; metastasis; hippo pathway ... See more keywords
Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.067
Abstract: SUMMARY Protein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings propelling… read more here.
Keywords: tumor suppressive; akt signaling; pi3k akt; pkc ... See more keywords
ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01832-3
Abstract: ING2 (Inhibitor of Growth 2) is a tumor suppressor gene that has been implicated in critical biological functions (cell-cycle regulation, replicative senescence, DNA repair and DNA replication), most of which are recognized hallmarks of tumorigenesis… read more here.
Keywords: mitochondria involved; ing2 tumor; suppressive protein; ing2 ... See more keywords
6mer seed toxicity in tumor suppressive microRNAs
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06526-1
Abstract: Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine… read more here.
Keywords: seed; 6mer seed; toxicity; cancer cells ... See more keywords
Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40857-3
Abstract: Gallbladder carcinoma (GBC) is a biliary tract cancer with few treatment options and poor prognosis. Radical surgery is the only potentially curative treatment option but most patients diagnosed with GBC are unresectable. Thus, there is… read more here.
Keywords: mir 145; gallbladder; activation stat1; gallbladder carcinoma ... See more keywords
miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmaa159
Abstract: miR-195-5p has been widely explored in various cancers and is considered as a tumor-suppressive microRNA. However, its roles in human lung cancer pathogenesis are not fully elucidated. In this study, we aimed to explore how… read more here.
Keywords: overexpression; mir 195; trxr2; human lung ... See more keywords
Tumor suppressive roles of eugenol in human lung cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.12508
Abstract: Eugenol, a natural compound available in Syzigium aromaticum (cloves), is exploited for various medicinal applications. Eugenol induces apoptosis and functions as an anti‐cancer drug in several types of tumors. We investigated the tumor suppressive role… read more here.
Keywords: eugenol human; cancer cells; human lung; lung cancer ... See more keywords
MiR‐1253 exerts tumor‐suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7‐H3)
Sign Up to like & getrecommendations! Published in 2020 at "Brain Pathology"
DOI: 10.1111/bpa.12829
Abstract: Of the four primary subgroups of medulloblastoma, the most frequent cytogenetic abnormality, i17q, distinguishes Groups 3 and 4 which carry the highest mortality; haploinsufficiency of 17p13.3 is a marker for particularly poor prognosis. At the… read more here.
Keywords: tumor suppressive; cdk6 cd276; expression; mir 1253 ... See more keywords