High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12434
Abstract: Polybromo‐1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl‐lysine residues. While BD2 has been found to bind acetylated histone H3 lysine… read more here.
Keywords: tumor suppressor; molecular tumor; binding h3k14ac; tumor ... See more keywords
EBP2, a novel NPM‐ALK‐interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12822
Abstract: The oncogenic fusion protein nucleophosmin‐anaplastic lymphoma kinase (NPM‐ALK), found in anaplastic large‐cell lymphoma (ALCL), localizes to the cytosol, nucleoplasm, and nucleolus. However, the relationship between its localization and transforming activity remains unclear. We herein demonstrated… read more here.
Keywords: suppressor p53; alk; npm alk; tumor suppressor ... See more keywords
MicroRNA‐204‐5p: A pivotal tumor suppressor
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DOI: 10.1002/cam4.5077
Abstract: MicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with a length of approximately 18‐25 nt nucleotides that regulate gene expression post‐transcriptionally. MiR‐204‐5p originates from the sixth intron of the transient receptor potential cation channel… read more here.
Keywords: tumor suppressor; microrna 204; mir 204; tumor ... See more keywords
Small‐Molecule Inhibitors of the Tumor Suppressor Fhit
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DOI: 10.1002/cbic.201700226
Abstract: The tumor suppressor Fhit and its substrate diadenosine triphosphate (Ap3A) are important factors in cancer development and progression. Fhit has Ap3A hydrolase activity and cleaves Ap3A into adenosine monophosphate (AMP) and adenosine diphosphate (ADP); this… read more here.
Keywords: fhit; suppressor fhit; tumor suppressor; small molecule ... See more keywords
A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia
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DOI: 10.1002/cmdc.202000972
Abstract: Targeting protein‐protein interactions (PPIs) with small‐molecule inhibitors has become a hotbed of modern drug development. In this review, we describe a new class of PPI inhibitors that block menin from binding to MLL proteins. Menin… read more here.
Keywords: tumor suppressor; leukemia; mll; chemistry ... See more keywords
Relationships between highly recurrent tumor suppressor alterations in 489 leiomyosarcomas
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DOI: 10.1002/cncr.33542
Abstract: Leiomyosarcoma (LMS) is the most common soft tissue and uterine sarcoma, but no standard therapy is available for recurrent or metastatic LMS. TP53, p16/RB1, and PI3K/mTOR pathway dysregulations are recurrent events, and some LMS express… read more here.
Keywords: tumor suppressor; suppressor alterations; relationships highly; alterations 489 ... See more keywords
A tumor suppressor Retinoblastoma1 is essential for embryonic development in the sea urchin
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Dynamics"
DOI: 10.1002/dvdy.113
Abstract: Embryonic cells and cancer cells share various cellular characteristics important for their functions. It has been thus proposed that similar mechanisms of regulation may be present in these otherwise disparate cell types. read more here.
Keywords: tumor suppressor; embryonic development; suppressor retinoblastoma1; retinoblastoma1 essential ... See more keywords
Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin‐6/STAT3 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29405
Abstract: Long noncoding RNAs can serve as oncogenes or tumor suppressors in human cancer; however, their biological functions and underlying mechanism in hepatocarcinogenesis are largely unknown. Here, we report a novel tumor suppressor long noncoding RNA… read more here.
Keywords: long noncoding; tumor suppressor; noncoding rna; stat3 ... See more keywords
BOK displays cell death‐independent tumor suppressor activity in non‐small‐cell lung carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30906
Abstract: As the genomic region containing the Bcl‐2‐related ovarian killer (BOK) locus is frequently deleted in certain human cancers, BOK is hypothesized to have a tumor suppressor function. In the present study, we analyzed primary non‐small‐cell… read more here.
Keywords: tumor suppressor; non small; bok; lung ... See more keywords
The role of tumor suppressor of resveratrol and prednisolone by downregulation of YKL‐40 expression in CCRF‐CEM cell line
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DOI: 10.1002/jcb.27659
Abstract: Acute lymphoblastic leukemia (ALL) is characterized by excessive accumulation of lymphoblast and progenitors. Leukemia is the most common cancer in children and ALL is the most common subtype. Many studies have shown that the YKL‐40… read more here.
Keywords: tumor suppressor; role tumor; pathology; cell ... See more keywords
Oncogenic and tumor suppressor genes expression in myeloproliferative neoplasms: The hidden side of a complex pathology
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24289
Abstract: The present study aimed to explore the changes in the expressions of six tumor‐related genes in myeloproliferative neoplasms (MPNs). The study population included 130 patients with MPNs (52 with chronic myeloid leukemia (CML), 49 with… read more here.
Keywords: oncogenic tumor; suppressor genes; tumor suppressor; pathology ... See more keywords