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   Articles with "tumor suppressor" as a keyword



High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12434

Abstract: Polybromo‐1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl‐lysine residues. While BD2 has been found to bind acetylated histone H3 lysine… read more here.

Keywords: tumor suppressor; molecular tumor; binding h3k14ac; tumor ... See more keywords
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EBP2, a novel NPM‐ALK‐interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53

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recommendations! Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12822

Abstract: The oncogenic fusion protein nucleophosmin‐anaplastic lymphoma kinase (NPM‐ALK), found in anaplastic large‐cell lymphoma (ALCL), localizes to the cytosol, nucleoplasm, and nucleolus. However, the relationship between its localization and transforming activity remains unclear. We herein demonstrated… read more here.

Keywords: suppressor p53; alk; npm alk; tumor suppressor ... See more keywords

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202405812

Abstract: NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto-oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss-of-function (LOF),… read more here.

Keywords: complex controls; mammary stem; crl7fbxw8 complex; tumor suppressor ... See more keywords

Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202413377

Abstract: Pharmacological reactivation of the tumor suppressor p53 remains a key challenge for the treatment of cancer. Acetylation Targeting Chimera (AceTAC), a novel technology is previously reported that hijacks lysine acetyltransferases p300/CBP to acetylate the p53Y220C… read more here.

Keywords: suppressor p53; tumor suppressor; p53; acetylation ... See more keywords

MicroRNA‐204‐5p: A pivotal tumor suppressor

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recommendations! Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.5077

Abstract: MicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with a length of approximately 18‐25 nt nucleotides that regulate gene expression post‐transcriptionally. MiR‐204‐5p originates from the sixth intron of the transient receptor potential cation channel… read more here.

Keywords: tumor suppressor; microrna 204; mir 204; tumor ... See more keywords
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Small‐Molecule Inhibitors of the Tumor Suppressor Fhit

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700226

Abstract: The tumor suppressor Fhit and its substrate diadenosine triphosphate (Ap3A) are important factors in cancer development and progression. Fhit has Ap3A hydrolase activity and cleaves Ap3A into adenosine monophosphate (AMP) and adenosine diphosphate (ADP); this… read more here.

Keywords: fhit; suppressor fhit; tumor suppressor; small molecule ... See more keywords
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A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia

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recommendations! Published in 2021 at "Chemmedchem"

DOI: 10.1002/cmdc.202000972

Abstract: Targeting protein‐protein interactions (PPIs) with small‐molecule inhibitors has become a hotbed of modern drug development. In this review, we describe a new class of PPI inhibitors that block menin from binding to MLL proteins. Menin… read more here.

Keywords: tumor suppressor; leukemia; mll; chemistry ... See more keywords
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Relationships between highly recurrent tumor suppressor alterations in 489 leiomyosarcomas

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recommendations! Published in 2021 at "Cancer"

DOI: 10.1002/cncr.33542

Abstract: Leiomyosarcoma (LMS) is the most common soft tissue and uterine sarcoma, but no standard therapy is available for recurrent or metastatic LMS. TP53, p16/RB1, and PI3K/mTOR pathway dysregulations are recurrent events, and some LMS express… read more here.

Keywords: tumor suppressor; suppressor alterations; relationships highly; alterations 489 ... See more keywords
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A tumor suppressor Retinoblastoma1 is essential for embryonic development in the sea urchin

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recommendations! Published in 2019 at "Developmental Dynamics"

DOI: 10.1002/dvdy.113

Abstract: Embryonic cells and cancer cells share various cellular characteristics important for their functions. It has been thus proposed that similar mechanisms of regulation may be present in these otherwise disparate cell types. read more here.

Keywords: tumor suppressor; embryonic development; suppressor retinoblastoma1; retinoblastoma1 essential ... See more keywords

Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin‐6/STAT3 signaling pathway

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recommendations! Published in 2018 at "Hepatology"

DOI: 10.1002/hep.29405

Abstract: Long noncoding RNAs can serve as oncogenes or tumor suppressors in human cancer; however, their biological functions and underlying mechanism in hepatocarcinogenesis are largely unknown. Here, we report a novel tumor suppressor long noncoding RNA… read more here.

Keywords: long noncoding; tumor suppressor; noncoding rna; stat3 ... See more keywords

BOK displays cell death‐independent tumor suppressor activity in non‐small‐cell lung carcinoma

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recommendations! Published in 2017 at "International Journal of Cancer"

DOI: 10.1002/ijc.30906

Abstract: As the genomic region containing the Bcl‐2‐related ovarian killer (BOK) locus is frequently deleted in certain human cancers, BOK is hypothesized to have a tumor suppressor function. In the present study, we analyzed primary non‐small‐cell… read more here.

Keywords: tumor suppressor; non small; bok; lung ... See more keywords