Tumor susceptibility gene 101 regulates predisposition to apoptosis via ESCRT machinery accessory proteins
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-12-0855
Abstract: The ESCRT-I protein TSG101 can mitigate endoplasmic reticulum stress–mediated apoptosis involving caspase 4/12 caused by MGRN1 depletion, probably contributing to neurodegeneration. TSG101 associates with ALIX to prevent predisposition to apoptosis, whereas ALIX–ALG-2 interaction favors a… read more here.
Keywords: 101 regulates; apoptosis; gene 101; tumor susceptibility ... See more keywords
The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease
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DOI: 10.3390/cancers12020450
Abstract: The multidomain protein encoded by the Tumor Susceptibility Gene 101 (TSG101) is ubiquitously expressed and is suggested to function in diverse intracellular processes. In this review, we provide a succinct overview of the main structural… read more here.
Keywords: 101 tsg101; susceptibility gene; tsg101; gene 101 ... See more keywords
WDR4 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cancer"
DOI: 10.7150/jca.83747
Abstract: Wilms tumor is the most common embryonal renal malignancy in children. WDR4 is an indispensable noncatalytic subunit of the RNA N7-methylguanosine (m7G) methyltransferase complex and plays an essential role in tumorigenesis. However, the relationship between… read more here.
Keywords: wilms tumor; tumor; tumor susceptibility; wdr4 gene ... See more keywords