Hyaluronic Acid-Modified Zeolitic Imidazolate Framework as a Drug Carrier for Aesculetin Delivery in Tumor-Targeted Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "ChemMedChem"
DOI: 10.1002/cmdc.202500732
Abstract: Efficient and tumor‐targeted drug delivery systems can significantly enhance therapeutic efficacy while reducing adverse effects. Herein, a one‐pot encapsulation method is employed to load the hydrophobic drug aesculetin (AE) into zeolitic imidazolate framework‐8 (ZIF‐8) nanocarriers… read more here.
Keywords: zeolitic imidazolate; tumor targeted; delivery; drug ... See more keywords
Preparation of a tumor-targeted drug-loading material, amphiphilic peptide P10, and analysis of its anti-tumor activity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Science: Materials in Medicine"
DOI: 10.1007/s10856-018-6204-8
Abstract: AbstractA new tumor-targeted drug-loading material, the amphiphilic peptide DGRGGGAAAA (P10) was designed and synthesized, and its self-assembly behavior, drug-loading effects and in vitro characteristics were studied. P10 was synthesized by solid-state synthesis and doxorubicin (DOX)… read more here.
Keywords: drug loading; drug; targeted drug; p10 ... See more keywords
Biosynthetic molecular imaging probe for tumor-targeted dual-modal fluorescence/magnetic resonance imaging.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120220
Abstract: Molecular imaging enables noninvasive visualization of cancer-related biological processes for tumor diagnostics; engineering molecular probes for accurate and efficient tumor imaging remains challenge. Herein, by using a biosynthetic strategy, we prepared a tumor-targeted fluorescence/magnetic resonance… read more here.
Keywords: probe; dual modal; magnetic resonance; molecular imaging ... See more keywords
N‐(2‐hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide‐a, a promising tumor‐targeted theranostic probe for photodynamic therapy and imaging
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.06.005
Abstract: ABSTRACT Tumor‐targeted photodynamic therapy (PDT) using polymeric photosensitizers is a promising therapeutic strategy for cancer treatment. In this study, we synthesized a pHPMA conjugated pyropheophorbide‐a (P‐PyF) as a cancer theranostic agent for PDT and photodynamic… read more here.
Keywords: photodynamic therapy; effect; pdt; pyf ... See more keywords
Luciferase-Decorated Gold Nanorods as Dual-Modal Contrast Agents for Tumor-Targeted High-Performance Bioluminescence/Photoacoustic Imaging.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c00817
Abstract: Gold nanorods (AuNRs) have been considered highly compelling materials for early cancer diagnosis and have aroused a burgeoning fascination among the biomedical sectors. By leveraging the versatile tunable optical properties of AuNRs, herein, we have… read more here.
Keywords: photoacoustic imaging; tumor targeted; gold nanorods; dual modal ... See more keywords
Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00509
Abstract: Use of tumor-targeted fluorescence dyes to help surgeons identify otherwise undetected tumor nodules, decrease the incidence of cancer-positive margins, and facilitate localization of malignant lymph nodes has demonstrated considerable promise for improving cancer debulking surgery.… read more here.
Keywords: carbonic anhydrase; near infrared; dye; tumor targeted ... See more keywords
Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b02009
Abstract: 6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist with robust anticancer efficacy; however, its therapeutic potential was hampered by its biodistribution and toxicity to normal tissues, specifically gastrointestinal (GI) tissues. To circumvent DON's toxicity, we synthesized a… read more here.
Keywords: diazo oxo; oxo norleucine; diazo; tumor targeted ... See more keywords
Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00883
Abstract: Tumor-targeted drug delivery systems offer not only the advantage of an enhanced therapeutic index, but also the possibility of overcoming the limitations that have largely restricted drug design to small, hydrophobic, "drug-like" molecules. Here, we… read more here.
Keywords: insertion; delivery; phlip; drug ... See more keywords
Tumor-Targeted Bacterial Vaccine Induces In Situ Immunogenic Cell Death for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Nano letters"
DOI: 10.1021/acs.nanolett.5c03938
Abstract: The immunosuppressive nature and low antigenicity of solid tumors present major obstacles for effective cancer vaccination. Here, we report a live bacteria-based vaccine platform engineered by coating attenuated Salmonella (SAL) with a cancer cell membrane… read more here.
Keywords: cancer; immunogenic cell; tumor targeted; tumor ... See more keywords
Manganese-Loaded pH-Responsive DNA Hydrogels Enable Tg-Guided Thyroid Tumor Targeted Magnetic Resonance Imaging
Sign Up to like & getrecommendations! Published in 2025 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.4c19676
Abstract: The diagnosis of metastatic and recurrent occult thyroid cancer presents a significant challenge. This study introduces a DNA-Mn hydrogel (M-TDH) that specifically targets thyroglobulin (Tg). This nanogel is loaded with paramagnetic Mn2+ for facilitating magnetic… read more here.
Keywords: tumor targeted; resonance imaging; magnetic resonance; dna ... See more keywords
Size-Tunable Strategies for a Tumor Targeted Drug Delivery System
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DOI: 10.1021/acscentsci.9b01139
Abstract: Nanoparticles have been widely used in tumor targeted drug delivery, while the antitumor effects are not always satisfactory due to the limited penetration and retention. As we all know, there is a paradox that nanoparticles… read more here.
Keywords: size tunable; drug delivery; size; targeted drug ... See more keywords