Preparation of a tumor-targeted drug-loading material, amphiphilic peptide P10, and analysis of its anti-tumor activity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Materials Science: Materials in Medicine"
DOI: 10.1007/s10856-018-6204-8
Abstract: AbstractA new tumor-targeted drug-loading material, the amphiphilic peptide DGRGGGAAAA (P10) was designed and synthesized, and its self-assembly behavior, drug-loading effects and in vitro characteristics were studied. P10 was synthesized by solid-state synthesis and doxorubicin (DOX)… read more here.
Keywords: drug loading; drug; targeted drug; p10 ... See more keywords
Biosynthetic molecular imaging probe for tumor-targeted dual-modal fluorescence/magnetic resonance imaging.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120220
Abstract: Molecular imaging enables noninvasive visualization of cancer-related biological processes for tumor diagnostics; engineering molecular probes for accurate and efficient tumor imaging remains challenge. Herein, by using a biosynthetic strategy, we prepared a tumor-targeted fluorescence/magnetic resonance… read more here.
Keywords: probe; dual modal; magnetic resonance; molecular imaging ... See more keywords
N‐(2‐hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide‐a, a promising tumor‐targeted theranostic probe for photodynamic therapy and imaging
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.06.005
Abstract: ABSTRACT Tumor‐targeted photodynamic therapy (PDT) using polymeric photosensitizers is a promising therapeutic strategy for cancer treatment. In this study, we synthesized a pHPMA conjugated pyropheophorbide‐a (P‐PyF) as a cancer theranostic agent for PDT and photodynamic… read more here.
Keywords: photodynamic therapy; effect; pdt; pyf ... See more keywords
Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00509
Abstract: Use of tumor-targeted fluorescence dyes to help surgeons identify otherwise undetected tumor nodules, decrease the incidence of cancer-positive margins, and facilitate localization of malignant lymph nodes has demonstrated considerable promise for improving cancer debulking surgery.… read more here.
Keywords: carbonic anhydrase; near infrared; dye; tumor targeted ... See more keywords
Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b02009
Abstract: 6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist with robust anticancer efficacy; however, its therapeutic potential was hampered by its biodistribution and toxicity to normal tissues, specifically gastrointestinal (GI) tissues. To circumvent DON's toxicity, we synthesized a… read more here.
Keywords: diazo oxo; oxo norleucine; diazo; tumor targeted ... See more keywords
Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00883
Abstract: Tumor-targeted drug delivery systems offer not only the advantage of an enhanced therapeutic index, but also the possibility of overcoming the limitations that have largely restricted drug design to small, hydrophobic, "drug-like" molecules. Here, we… read more here.
Keywords: insertion; delivery; phlip; drug ... See more keywords
Size-Tunable Strategies for a Tumor Targeted Drug Delivery System
Sign Up to like & getrecommendations! Published in 2020 at "ACS Central Science"
DOI: 10.1021/acscentsci.9b01139
Abstract: Nanoparticles have been widely used in tumor targeted drug delivery, while the antitumor effects are not always satisfactory due to the limited penetration and retention. As we all know, there is a paradox that nanoparticles… read more here.
Keywords: size tunable; drug delivery; size; targeted drug ... See more keywords
A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.7b02675
Abstract: Incorporation of T1 and T2 contrast material in one nanosystem performing their respective MR contrast role and simultaneously serving as an efficient drug delivery system (DDS) has a significant potential application for clinical diagnosis and… read more here.
Keywords: chemotherapy; dual mode; contrast; targeted dual ... See more keywords
A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07195-w
Abstract: The costimulation of immune cells using first-generation anti-4-1BB monoclonal antibodies (mAbs) has demonstrated anti-tumor activity in human trials. Further clinical development, however, is restricted by significant off-tumor toxicities associated with FcγR interactions. Here, we have… read more here.
Keywords: antibody; toxicity; anti tumor; 1bb agonistic ... See more keywords
Recent advances in improving tumor-targeted delivery of imaging nanoprobes.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/d0bm00761g
Abstract: Tumor-targeted delivery of imaging nanoprobes provides a promising approach for the precision imaging diagnosis of cancers. Nanoprobes with desired bio-nano interface properties can preferably enter tumor tissues through the vascular endothelium, penetrate into deep tissues,… read more here.
Keywords: imaging nanoprobes; tumor targeted; delivery imaging; targeted delivery ... See more keywords
Tumor-targeted nano-delivery system of therapeutic RNA.
Sign Up to like & getrecommendations! Published in 2022 at "Materials horizons"
DOI: 10.1039/d1mh01969d
Abstract: The birth of RNAi technology has pioneered actionability at the molecular level. Compared to DNA, RNA is less stable and therefore requires more demanding delivery vehicles. With their flexible size, shape, structure, and accessible surface… read more here.
Keywords: targeted nano; tumor targeted; delivery; delivery system ... See more keywords