Somatic tumor testing implications for Lynch syndrome germline genetic testing.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2022.02.010
Abstract: Clinicians involved in cancer treatment often utilize somatic tumor sequencing to help tailor chemotherapy and immunotherapy. However, somatic tumor sequencing can also identify patients at risk for germline pathogenic variants causing cancer predisposition syndromes like… read more here.
Keywords: tumor; tumor testing; lynch syndrome; tumor sequencing ... See more keywords
Year 1: Experiences of a tertiary cancer centre following implementation of reflex BRCA1 and BRCA2 tumor testing for all high-grade serous ovarian cancers in a universal healthcare system.
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2020.06.507
Abstract: OBJECTIVE This study compares the rate and time to genetic referral, and patient uptake of germline genetic services, before and after implementation of reflex BRCA1/2 tumor testing for high-grade serous ovarian cancer (HGSOC) in a… read more here.
Keywords: reflex brca1; implementation reflex; tumor testing; tumor ... See more keywords
Reliability of Tumor Testing Compared to Germline Testing for Detecting BRCA1 and BRCA2 Mutations in Patients with Epithelial Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm11070593
Abstract: Background: BRCA 1/2 mutation status has become one of the most important parameters for treatment decision in patients with epithelial ovarian cancer (EOC). The aim of this study was to compare tumor DNA with blood… read more here.
Keywords: patients epithelial; epithelial ovarian; germline testing; tumor testing ... See more keywords