Evidence of pseudoprogression in patients treated with PD1/PDL1 antibodies across tumor types
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DOI: 10.1002/cam4.2797
Abstract: PD(L)1 antibodies (anti‐PD(L)‐1) have been a major breakthrough in several types of cancer. Novel patterns of response and progression have been described with anti‐PD(L)‐1. We aimed at characterizing pseudoprogression (PSPD) among patients with various solid… read more here.
Keywords: tumor types; patients treated; evidence pseudoprogression; pseudoprogression ... See more keywords
Tumors in the cauda equina: A SEER analysis of tumor types and predictors of outcome
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.09.068
Abstract: Caudaequinatumors are histologically diverse. International Classification of Diseases for Oncology (ICD-O3) confers dedicated site code (C72. 1) for cauda equina. This code is excluded during analyses of other primary spinal cord tumors. In this retrospective… read more here.
Keywords: tumor types; age; analysis; cauda equina ... See more keywords
Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients
Sign Up to like & getrecommendations! Published in 2017 at "Nature medicine"
DOI: 10.1038/nm.4333
Abstract: Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically defined… read more here.
Keywords: tumor types; clinical sequencing; 000 patients; cancer ... See more keywords
Gene fusions in superficial mesenchymal neoplasms: Emerging entities and useful diagnostic adjuncts.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2023.04.014
Abstract: Cutaneous mesenchymal neoplasms are diagnostically challenging because of their overlapping morphology, and, often, the limited tissue in skin biopsy specimens. Molecular and cytogenetic techniques have identified characteristic gene fusions in many of these tumor types,… read more here.
Keywords: cell; mesenchymal neoplasms; gene fusions; tumor ... See more keywords
Pattern of MUC6 expression across 119 different tumor types: A tissue microarray study on 15 412 tumors.
Sign Up to like & getrecommendations! Published in 2023 at "Pathology international"
DOI: 10.1111/pin.13322
Abstract: Mucin 6 (MUC6) is a secreted gel-forming mucin covering the surfaces of gastrointestinal and other tissues. Published work demonstrates that MUC6 can also be expressed in several cancer types and can aid in the distinction… read more here.
Keywords: tumor types; muc6 expression; tumor; different tumor ... See more keywords
Pan-cancer landscape of CD274 (PD-L1) copy number changes in 244 584 patient samples and the correlation with PD-L1 protein expression
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002680
Abstract: Introduction Several studies have shown clinical outcomes data that support the use of CD274 (PD-L1) copy-number (CN) gains and/or losses as a biomarker for immune checkpoint inhibitor (ICPI). Here, we present the landscape of CD274… read more here.
Keywords: tumor types; cd274 changes; 244 584; cd274 ... See more keywords
Abstract A008: PDX-based screen to evaluate and compare approved CDK4/6 inhibitors in breast cancer and determine palbociclib efficacy in additional tumor types
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a008
Abstract: Background: FDA-approved CDK 4/6 inhibitors (CDK4/6i) including palbociclib, abemaciclib, and ribociclib have demonstrated clinical benefit in treating hormone receptor-positive (HR+) breast cancer. However, whether there is differential sensitivity to each therapy in vivo is unknown.… read more here.
Keywords: palbociclib; tumor types; cancer; breast cancer ... See more keywords
Abstract 3432: Ataxia-telangiectasia mutated loss of function displays variant and tissue specific differences across tumor types
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3432
Abstract: Introduction: ATM loss of function (LOF) in cancer may serve as a predictive biomarker of response for antitumor therapies. However, clinical studies of targeted treatments in ATM-aberrant patients have yielded mixed results; thus, identifying the… read more here.
Keywords: loss function; loss; cancer; tumor types ... See more keywords
Abstract SP084: Replication stress response defects predict responses to ICT in non-hypermutated tumors
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs20-sp84
Abstract: Immune checkpoint blockade (ICT) has provided robust, durable responses to a subset of patients. Many initial ICT trials were focused on highly mutated cancer types, such as melanoma and lung cancer, largely predicated on the… read more here.
Keywords: response; tumor types; replication; cancer ... See more keywords
Validation of Digital Microscopy Compared With Light Microscopy for the Diagnosis of Canine Cutaneous Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary Pathology"
DOI: 10.1177/0300985818755254
Abstract: Integration of new technologies, such as digital microscopy, into a highly standardized laboratory routine requires the validation of its performance in terms of reliability, specificity, and sensitivity. However, a validation study of digital microscopy is… read more here.
Keywords: tumor types; canine cutaneous; light microscopy; microscopy ... See more keywords
Ovarian cancer: diagnostic accuracy and tumor types distribution in East Africa compared to North America
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostic Pathology"
DOI: 10.1186/s13000-020-01000-3
Abstract: Background Ovarian cancer is a spectrum of several histologically distinct tumor types that differ in etiology, response to therapy, and prognosis. In resource-limited settings, the diagnosis of ovarian cancer can be challenging. This study describes… read more here.
Keywords: cancer; tumor types; ovarian cancer; diagnostic accuracy ... See more keywords