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Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202110305
Abstract: Tumor-targeted antibody (mAb)/fragment-conjugated nanoparticles (NPs) represent an innovative strategy for improving the local delivery of small molecules. However, the physicochemical properties of full mAb-NPs and fragment-NPs-that is, NP material, size, charge, as well as the…
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Keywords:
tumor;
tumor uptake;
mab nps;
physicochemical properties ... See more keywords
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Published in 2017 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-017-1097-3
Abstract: PurposeIncreased expression of the αvβ6 integrin correlates with advanced tumor grade and poor clinical outcome, identifying αvβ6 as a prognostic indicator and an attractive target for molecular imaging. This work investigated the ability of a…
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Keywords:
tumor uptake;
diabody;
cys diabody;
expression ... See more keywords
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Published in 2020 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-019-01468-6
Abstract: Purpose The s mall peptide TMTP1 (NVVRQ) has been proved to target a series of highly metastatic tumor cells. The aim of this study was to develop a new agent based on TMTP1 conjugated with…
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Keywords:
dota tmtp1;
tumor uptake;
synthesis application;
tumor ... See more keywords
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2
Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10139-6
Abstract: [177Lu]Lu-DOTA-NNV003, a radioimmunoconjugate targeting CD37, is developed as novel radioimmunotherapy (RIT) treatment for patients with B cell non-Hodgkin’s lymphoma (NHL). Since patients are at risk for developing hematological toxicities due to CD37 expression on normal…
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Keywords:
tumor uptake;
89zr sucdf;
tumor;
pet imaging ... See more keywords
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1
Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3028
Abstract: BACKGROUND: ERY974, a modified monoclonal IgG4 bispecific antibody directed against human CD3 on T cells and glypican 3 (GPC3) on tumor cell, is currently in phase I clinical trial. The oncofetal protein GPC3 is overexpressed…
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Keywords:
mouse models;
pet;
89zr ery974;
tumor uptake ... See more keywords
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Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1136
Abstract: Introduction Ipilimumab, a monoclonal antibody targeting CTLA-4, is approved for the treatment of metastatic melanoma and significantly improves overall survival. Because of the high costs and the potential serious toxicity of ipilimumab, it is of…
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Keywords:
labeled ipilimumab;
treatment;
ipilimumab;
metastatic melanoma ... See more keywords
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Published in 2022 at "Current drug metabolism"
DOI: 10.2174/1389200223666220113101004
Abstract: BACKGROUND HER2 over-expression plays a crucial role in the cancer treatment protocol. This study evaluates the effectiveness of kidney organic anion and cation transport inhibitors on the tumor uptake of 99mTc-HYNIC-(Ser)3-LTVPWY radiotracer in SKOV-3 tumor-bearing…
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Keywords:
radioactivity;
tumor uptake;
radiolabeled peptide;
transport inhibitors ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010862
Abstract: Heptamethine cyanine dyes are widely used for in vivo near-infrared (NIR) fluorescence imaging and NIR laser-induced cancer phototherapy due to their good optical properties. Since most of heptamethine cyanine dyes available commercially are highly hydrophobic,…
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Keywords:
cyanine dyes;
tumor;
tumor uptake;
uptake retention ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093782
Abstract: To investigate and compare the pharmacokinetic profile and anti-cancer activity of fluorinated and iodinated photosensitizers (PSs), the 3-(1′-(o-fluorobenzyloxy)ethyl pyropheophorbide and the corresponding meta-(m-) and para (p-) fluorinated analogs (methyl esters and carboxylic acids) were synthesized.…
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Keywords:
tumor uptake;
cancer activity;
anti cancer;
difference ... See more keywords
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1
Published in 2018 at "International journal of oncology"
DOI: 10.3892/ijo.2018.4596
Abstract: The non‑natural amino acid positron emission tomography tracers, 2‑amino[3‑11C]isobutyric acid ([3‑11C]AIB) and 2‑amino[11C]methyl‑isobutyric acid ([11C]MeAIB), are metabolically stable in vivo and accumulate in tumors. [3‑11C]AIB is transported into cells mainly via the amino acid transport system A…
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Keywords:
amino 11c;
tumor uptake;
isobutyric acid;
amino ... See more keywords
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Published in 2017 at "Theranostics"
DOI: 10.7150/thno.18078
Abstract: Minimizing the sequestration of nanomaterials (NMs) by the reticuloendothelial system (RES) can enhance the circulation time of NMs, and thus increase their tumor-specific accumulation. Liposomes are generally regarded as safe (GRAS) agents that can block…
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Keywords:
optimizing liposome;
tumor uptake;
improved tumor;
uptake optimizing ... See more keywords