Development of Effective Tumor Vaccine Strategies Based on Immune Response Cascade Reactions.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100299
Abstract: To solve the problems of high toxicity and poor efficacy of existing tumor treatment methods, researchers have developed a variety of tumor immunotherapies. Among them, tumor vaccines activate antigen-presenting cells and T lymphocytes upstream of… read more here.
Keywords: effective tumor; tumor vaccines; tumor vaccine; development effective ... See more keywords
Rapid surface display of mRNA antigens by bacteria-derived outer membrane vesicles for a personalized tumor vaccine.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202109984
Abstract: Therapeutic mRNA vaccination is an attractive approach to trigger antitumor immunity. However, the mRNA delivery technology for customized tumor vaccine is still limited. Herein, we employed bacteria-derived outer membrane vesicles (OMVs) as an mRNA delivery… read more here.
Keywords: tumor; bacteria derived; tumor vaccine; derived outer ... See more keywords
Further exploring the feasibility of dendritic cells-targeted biomimetic Texosomes as a therapeutic and preventive tumor-vaccine
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DOI: 10.1039/c6ra26434d
Abstract: Targeting tumor cells with immunotherapy by a dendritic cells-targeted vaccination is a potential treatment option. In previous research, we preliminarily proved the immune activity of hTERT-HSP70 loaded DEC205McAb Texosomes on H22 hepato-carcinoma bearing mice. In… read more here.
Keywords: cells targeted; dec205mcab texosomes; tumor vaccine; dendritic cells ... See more keywords
Peptidic microarchitecture-trapped tumor vaccine combined with immune checkpoint inhibitor or PI3Kγ inhibitor can enhance immunogenicity and eradicate tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003564
Abstract: Background With the rapid development of immune checkpoint inhibitors and neoantigen (NeoV)-based personalized tumor vaccines, tumor immunotherapy has shown promising therapeutic results. However, the limited efficacy of available tumor vaccines impedes the development of personalized… read more here.
Keywords: tumor; pma neov; tumor vaccine; pi3k inhibitor ... See more keywords
Role of immune checkpoint inhibitor, tumor vaccine and cellular immunotherapy in advanced non-small-cell lung cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e21056
Abstract: e21056Background: We previously identified that immunotherapy including immune checkpoint inhibitor (ICI), tumor vaccine (TV) and cellular immunotherapy (CIM) improved overall survival (OS) and pro... read more here.
Keywords: immune checkpoint; cellular immunotherapy; immunotherapy; tumor vaccine ... See more keywords
PD-1 blockage combined with vaccine therapy can facilitate immune infiltration in tumor microenvironment of Lynch syndrome colon cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.877833
Abstract: Background: Lynch syndrome is a genetic disease resulting from mismatch repair gene mutation. Vaccine therapy can enhance the immunogenicity of Lynch syndrome and improve the therapeutic efficacy of immunotherapy. However, there is no approved Lynch… read more here.
Keywords: vaccine therapy; lynch syndrome; tumor; tumor vaccine ... See more keywords
A Novel Therapeutic Tumor Vaccine Targeting MUC1 in Combination with PD-L1 Elicits Specific Anti-Tumor Immunity in Mice
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DOI: 10.3390/vaccines10071092
Abstract: Dendritic cells (DCs), as professional antigen-presenting cells (APCs), play a key role in the initiation and regulation of humoral and cellular immunity. DC vaccines loaded with different tumor-associated antigens (TAAs) have been widely used to… read more here.
Keywords: anti tumor; novel therapeutic; tumor; immunity ... See more keywords
Experimental study on the induction of cytotoxic T lymphocyte killing effects and dendritic-cell-based tumor vaccine prepared by high-intensity focused ultrasound
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_2291_21
Abstract: Aims: This study was conducted to explore the high-intensity focused ultrasound (HIFU) prepared antigen-sensitized dendritic cells (DC) and the induction of cytotoxic T lymphocyte (CTL) killing effects by DC and to observe their anti-tumor immunity… read more here.
Keywords: vaccine prepared; cell; group; based tumor ... See more keywords