Jet-Lagged Nanoparticles Enhanced Immunotherapy Efficiency through Synergistic Reconstruction of Tumor Microenvironment and Normalized Tumor Vasculature.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000075
Abstract: Lactic acid (LA), an anaerobic glycolysis metabolite normally oversecreted by tumor cells, can inhibit the activity of T cells and stimulate the rapid proliferation and migration of tumor endothelial cells (TECs), thereby limiting the synergistic treatment… read more here.
Keywords: tumor vasculature; jet lagged; lagged nanoparticles; tumor ... See more keywords
Combination drug delivery via multilamellar vesicles enables targeting of tumor cells and tumor vasculature
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26566
Abstract: Blood vessel development is critical for the continued growth and progression of solid tumors and, therefore, makes an attractive target for improving cancer therapy. Indeed, vascular‐targeted therapies have been extensively explored but they have shown… read more here.
Keywords: combination; tumor vasculature; delivery; drug ... See more keywords
Evaluation of Tumor Vasculature Using a Syngeneic Tumor Model in Wild-Type and Genetically Modified Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7595-2_17
Abstract: The relevance of tumor vasculature has been extensively recognized, and it is still the focus of numerous lines of research for basic, translational, and clinical scientists. Indeed, the knowledge of some of its regulatory mechanisms… read more here.
Keywords: vasculature; tumor vasculature; genetically modified; vasculature using ... See more keywords
Quantifying Tumor and Vasculature Deformations during Laryngoscopy
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DOI: 10.1007/s10439-021-02896-8
Abstract: Retractors and scopes used in head and neck surgery to provide adequate surgical exposure also deform critical structures in the region. Surgeons typically use preoperative imaging to plan and guide their tumor resections, however the… read more here.
Keywords: tumor; tumor vasculature; quantifying tumor; preoperative imaging ... See more keywords
Tumor vasculature normalization by orally fed erlotinib to modulate the tumor microenvironment for enhanced cancer nanomedicine and immunotherapy.
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DOI: 10.1016/j.biomaterials.2017.09.021
Abstract: The abnormal tumor vasculature is one of key reasons that lead to the limited tumor perfusion as well as hypoxic and immunosuppressive tumor microenvironment (TME). Herein, we uncover that by normalizing the tumor vasculature with… read more here.
Keywords: immunotherapy; tumor vasculature; cancer; tumor microenvironment ... See more keywords
Ultra-small nanocluster mediated synthesis of Nd3+-doped core-shell nanocrystals with emission in the second near-infrared window for multimodal imaging of tumor vasculature.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.05.021
Abstract: In-vivo intravital short wavelength infrared (SWIR, 1000-2300 nm) fluorescence imaging has attracted considerable attention in the imaging of tumor vasculature due to its low background, high sensitivity, and deep penetration. It can noninvasively provide dynamic feedback… read more here.
Keywords: imaging tumor; tumor vasculature; nd3 doped; doped core ... See more keywords
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.03.005
Abstract: Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal warheads. Here, we demonstrate that… read more here.
Keywords: tumor vasculature; cancer; cells tumor; cd276 positive ... See more keywords
Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b12216
Abstract: Manganese oxide nanoparticles (Mn3O4 NPs) have attracted a great deal of attention in the field of biomedical imaging because of their ability to create an enhanced imaging signal in MRI as novel potent T1 contrast… read more here.
Keywords: vasculature targeted; manganese oxide; 64cu nota; tumor vasculature ... See more keywords
RGD delivery of truncated coagulase to tumor vasculature affords local thrombotic activity to induce infarction of tumors in mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05326-9
Abstract: Induction of thrombosis in tumor vasculature represents an appealing strategy for combating cancer. Herein, we combined unique intrinsic coagulation properties of staphylocoagulase with new acquired functional potentials introduced by genetic engineering, to generate a novel… read more here.
Keywords: tumor vasculature; thrombotic activity; activity; truncated coagulase ... See more keywords
Design Optimization of Tumor Vasculature-Bound Nanoparticles
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DOI: 10.1038/s41598-018-35675-y
Abstract: Nanotherapy may constitute a promising approach to target tumors with anticancer drugs while minimizing systemic toxicity. Computational modeling can enable rapid evaluation of nanoparticle (NP) designs and numerical optimization. Here, an optimization study was performed… read more here.
Keywords: tumor vasculature; drug; design optimization; optimization ... See more keywords
Exercise during preoperative therapy increases tumor vascularity in pancreatic tumor patients
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DOI: 10.1038/s41598-019-49582-3
Abstract: The efficacy of chemotherapy is reduced by dysfunctional tumor vasculature, which may limit chemotherapy delivery to tumors. Preclinical studies have shown that moderate aerobic exercise improves tumor vascular function and increases chemotherapy efficacy in mouse… read more here.
Keywords: chemotherapy; tumor vascular; tumor vasculature; therapy ... See more keywords