Methodological Advancements for Investigating Intra-tumoral Heterogeneity in Breast Cancer at the Bench and Bedside
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-020-09470-3
Abstract: There is a major need to overcome therapeutic resistance and metastasis that eventually arises in many breast cancer patients. Therapy resistant and metastatic tumors are increasingly recognized to possess intra-tumoral heterogeneity (ITH), a diversity of… read more here.
Keywords: cancer; tumoral heterogeneity; intra tumoral; breast cancer ... See more keywords
Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity
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DOI: 10.1038/s41467-021-27667-w
Abstract: Glioblastoma is an aggressive form of brain cancer with well-established patterns of intra-tumoral heterogeneity implicated in treatment resistance and progression. While regional and single cell transcriptomic variations of glioblastoma have been recently resolved, downstream phenotype-level… read more here.
Keywords: glioblastoma; heterogeneity; model intra; tumoral heterogeneity ... See more keywords
Single Nuclear RNA Sequencing Highlights Intra-Tumoral Heterogeneity and Tumor Microenvironment Complexity in Testicular Embryonic Rhabdomyosarcoma
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DOI: 10.2147/jir.s343068
Abstract: Background Testicular embryonic rhabdomyosarcoma (ERMS) is a rare soft tissue tumor in children featured with high intra-tumoral heterogeneity. In this study, we aimed to comprehensively delineate the testicular ERMS intra-tumoral heterogeneity and tumor microenvironment. Methods… read more here.
Keywords: intra tumoral; embryonic rhabdomyosarcoma; tumoral heterogeneity; testicular embryonic ... See more keywords