IL-36γ and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and Wnt Signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202103035
Abstract: Inflammatory bowel disease and colorectal cancer are associated with dysregulation of cytokine networks. However, it is challenging to target cytokines for effective intervention because of the overlapping functions and unpredictable interactions of cytokines in such… read more here.
Keywords: cell matrix; matrix adhesion; reciprocally regulate; tumorigenesis ... See more keywords
Transforming Growth Factor Beta Promotes Inflammation and Tumorigenesis in Smad4-Deficient Intestinal Epithelium in a YAP-Dependent Manner.
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DOI: 10.1002/advs.202300708
Abstract: Transforming growth factor beta (TGF-β), a multifunctional cytokine, plays critical roles in immune responses. However, the precise role of TGF-β in colitis and colitis-associated cancer remains poorly defined. Here, it is demonstrated that TGF-β promotes… read more here.
Keywords: transforming growth; tumorigenesis; smad4 deficient; yap ... See more keywords
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c‐Myc‐mediated positive feedback loop
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12349
Abstract: Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent malignancies worldwide and is characterized by unfavorable prognosis, high lymph node metastasis and early recurrence. However, the molecular events regulating HNSCC tumorigenesis… read more here.
Keywords: cell carcinoma; head neck; tumorigenesis; squamous cell ... See more keywords
Iron imbalance in cancer: Intersection of deficiency and overload
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DOI: 10.1002/cam4.4761
Abstract: Iron, an essential trace element, plays a complex role in tumour biology. While iron causes cancer clearance through toxic free radical generation, iron‐induced free radical flux also acts as a cancer promoter. These fates majorly… read more here.
Keywords: iron; cancer; tumorigenesis; deficiency overload ... See more keywords
The complex role of telocytes in female prostate tumorigenesis in a rodent model
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DOI: 10.1002/cbin.11816
Abstract: The prostate is not an organ exclusive to the male. It is also found in females of several species, including humans, in which part of the Skene gland is homologous to the male prostate. Evidence… read more here.
Keywords: rodent model; tumorigenesis; role; complex role ... See more keywords
Multiple biological processes may be associated with tumorigenesis under NUP88‐overexpressed condition
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DOI: 10.1002/gcc.22417
Abstract: Overexpression of the nucleoporin NUP88 has been observed in a large number of tumors and has been experimentally proven to promote tumorigenesis. However, the mechanism underlying the tumor‐promoting activity of overexpressed NUP88 is not clear.… read more here.
Keywords: nup88; tumorigenesis nup88; tumorigenesis; overexpressed condition ... See more keywords
Hepatitis B Virus–Upregulated LNC‐HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity
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DOI: 10.1002/hep.30098
Abstract: Recent studies have indicated that a number of long noncoding RNAs (lncRNAs) are dysregulated in hepatocellular carcinoma, while their aberrant expressions are associated with tumorigenesis and poor prognosis. To identify hepatitis B virus (HBV)‐related lncRNAs,… read more here.
Keywords: tumorigenesis; hur1 promotes; cell proliferation; lnc hur1 ... See more keywords
RPB5‐Mediating Protein Promotes Cholangiocarcinoma Tumorigenesis and Drug Resistance by Competing With NRF2 for KEAP1 Binding
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DOI: 10.1002/hep.30962
Abstract: Cancer cell survival depends on the balance between reactive oxygen species production and scavenging, which is regulated primarily by NRF2 during tumorigenesis. Here, we demonstrate that deletion of RBP5‐mediating protein (RMP) in an autonomous mouse… read more here.
Keywords: mediating protein; tumorigenesis; rpb5 mediating; promotes cholangiocarcinoma ... See more keywords
Feedback-regulated transcriptional repression of FBXO31 by c-Myc triggers ovarian cancer tumorigenesis.
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DOI: 10.1002/ijc.33854
Abstract: FBXO31, a member of F-box protein family, has been shown to play an important role in preventing tumorigenesis by preserving genomic stability during cell proliferations as well as upon genotoxic stresses. Inactivation of FBXO31 due… read more here.
Keywords: tumorigenesis; fbxo31; ovarian cancer; expression ... See more keywords
Metformin inhibits tumorigenesis in HBV‐induced hepatocellular carcinoma by suppressing HULC overexpression caused by HBX
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DOI: 10.1002/jcb.26555
Abstract: We aimed to understand whether metformin imposes the inhibitory effect on the HBV‐associated tumorigenesis by regulating the HULC and its downstream signaling pathway. Luciferase assay, RT‐PCR, and Western‐blot, MTT and flow cytometry analysis were performed… read more here.
Keywords: hulc; tumorigenesis; hbv; metformin ... See more keywords
N6‐methyladenosine modification participates in neoplastic immunoregulation and tumorigenesis
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DOI: 10.1002/jcp.30730
Abstract: This review aims to provide insight into the role of N6‐methyladenosine (m6A) modification in neoplastic immunity and subsequent tumorigenesis. m6A modification, which is catalyzed by methyltransferases, demethylases and reader proteins, has emerged as a widespread… read more here.
Keywords: modification participates; modification; m6a modification; tumorigenesis ... See more keywords