Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12320
Abstract: TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial‐to‐mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self‐renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of… read more here.
Keywords: glioblastoma; loss function; tumorigenicity; human gbm ... See more keywords
PlGF Knockdown Decreases Tumorigenicity and Stemness Properties of Spheroid Body Cells Derived from Gastric Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25762
Abstract: Placental growth factor (PlGF) a member of the vascular endothelial growth factor family regulates some cell processes such as survival, growth of vascular endothelial cells, invasiveness, and also involves in pathological angiogenesis and metastasis in… read more here.
Keywords: gastric cancer; body cells; spheroid body; tumorigenicity ... See more keywords
The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.01.018
Abstract: Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the nuclear receptor superfamily of PPARs (PPARα, PPARβ/δ, PPARγ). Numerous studies have concentrated on the key role of PPARs in inflammation and a variety of cancers which include… read more here.
Keywords: ppar; peroxisome proliferator; proliferator activated; cancer ... See more keywords
Genome-wide Screen for Culture Adaptation and Tumorigenicity-Related Genes in Human Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2018.12.031
Abstract: Summary Human pluripotent stem cells (hPSCs) acquire genetic changes during their propagation in culture that can affect their use in research and future therapies. To identify the key genes involved in selective advantage during culture… read more here.
Keywords: human pluripotent; pluripotent stem; tumorigenicity; culture ... See more keywords
Tumorigenicity assessment of cell therapy products: the need for global consensus and points to consider.
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.10.001
Abstract: Pluripotent stem cells offer the potential for an unlimited source for cell therapy products. However, there is concern regarding the tumorigenicity of these products in humans, mainly due to the possible unintended contamination of undifferentiated… read more here.
Keywords: cell therapy; assessment cell; therapy products; tumorigenicity ... See more keywords
Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.03.007
Abstract: Summary A point mutation in the BRAF gene, leading to a constitutively active form of the protein, is present in 45%–60% of patients and acts as a key driver in melanoma. Shortly after therapy induction,… read more here.
Keywords: melanoma; melanoma derived; tumorigenicity; derived ipccs ... See more keywords
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12001-2
Abstract: Despite the development of adjuvant therapies, glioblastoma (GBM) patients remain incurable, thus justifying the urgent need of new therapies. CDK5 plays a critical role in GBM and is a potential target for GBM. However, the… read more here.
Keywords: trim59; cdk5 dependent; nuclear translocation; tumorigenicity ... See more keywords
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.
Sign Up to like & getrecommendations! Published in 2021 at "Nature cell biology"
DOI: 10.1038/s41556-021-00639-4
Abstract: Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However, EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that there is redundant EGFR activation. Circular RNAs are covalently closed RNA transcripts… read more here.
Keywords: egfr signalling; rna; cad; activation ... See more keywords
PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes
Sign Up to like & getrecommendations! Published in 2017 at "Carcinogenesis"
DOI: 10.1093/carcin/bgx062
Abstract: Breast cancer (BC) is a highly heterogeneous disease, both at the pathological and molecular level, and several chromatin-associated proteins play crucial roles in BC initiation and progression. Here, we demonstrate the role of PSIP1 (PC4… read more here.
Keywords: psip1 p75; p75; cell cycle; tumorigenicity ... See more keywords
Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac157
Abstract: BACKGROUND Glioblastoma multiforme and other solid malignancies are heterogeneous, containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known as POU5F1, is a key transcription factor in the self-renewal, proliferation, and differentiation of… read more here.
Keywords: glioblastoma; tumorigenicity; oct4a palmitoylation; gscs ... See more keywords
Hydroxyacid Oxidase 2 (HAO2) Inhibits the Tumorigenicity of Hepatocellular Carcinoma and Is Negatively Regulated by miR-615-5p
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/5003930
Abstract: Background Hepatocellular carcinoma (HCC) is the sixth most common kind of cancer worldwide and the third leading cause of cancer mortality. Although a few studies have shown that hydroxyacid oxidase 2 (HAO2) may prevent HCC… read more here.
Keywords: hepatocellular carcinoma; hao2; hcc; expression ... See more keywords