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   Articles with "tumorigenicity" as a keyword



Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma

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recommendations! Published in 2018 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12320

Abstract: TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial‐to‐mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self‐renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of… read more here.

Keywords: glioblastoma; loss function; tumorigenicity; human gbm ... See more keywords

PlGF Knockdown Decreases Tumorigenicity and Stemness Properties of Spheroid Body Cells Derived from Gastric Cancer Cells

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recommendations! Published in 2017 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.25762

Abstract: Placental growth factor (PlGF) a member of the vascular endothelial growth factor family regulates some cell processes such as survival, growth of vascular endothelial cells, invasiveness, and also involves in pathological angiogenesis and metastasis in… read more here.

Keywords: gastric cancer; body cells; spheroid body; tumorigenicity ... See more keywords

Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis

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recommendations! Published in 2024 at "Molecular Neurobiology"

DOI: 10.1007/s12035-024-04002-0

Abstract: Exosomes play a crucial role in regulating crosstalk between tumor and tumor stem-like cells through their cargo molecules. Circular RNAs (circRNAs) have recently been demonstrated to be critical factors in tumorigenesis. This study focuses on… read more here.

Keywords: tumorigenicity; circznf800; like cells; stem like ... See more keywords

The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity.

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recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2018.01.018

Abstract: Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the nuclear receptor superfamily of PPARs (PPARα, PPARβ/δ, PPARγ). Numerous studies have concentrated on the key role of PPARs in inflammation and a variety of cancers which include… read more here.

Keywords: ppar; peroxisome proliferator; proliferator activated; cancer ... See more keywords

Genome-wide Screen for Culture Adaptation and Tumorigenicity-Related Genes in Human Pluripotent Stem Cells

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recommendations! Published in 2019 at "iScience"

DOI: 10.1016/j.isci.2018.12.031

Abstract: Summary Human pluripotent stem cells (hPSCs) acquire genetic changes during their propagation in culture that can affect their use in research and future therapies. To identify the key genes involved in selective advantage during culture… read more here.

Keywords: human pluripotent; pluripotent stem; tumorigenicity; culture ... See more keywords

Tumorigenicity assessment of cell therapy products: the need for global consensus and points to consider.

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.10.001

Abstract: Pluripotent stem cells offer the potential for an unlimited source for cell therapy products. However, there is concern regarding the tumorigenicity of these products in humans, mainly due to the possible unintended contamination of undifferentiated… read more here.

Keywords: cell therapy; assessment cell; therapy products; tumorigenicity ... See more keywords

Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response

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recommendations! Published in 2017 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2017.03.007

Abstract: Summary A point mutation in the BRAF gene, leading to a constitutively active form of the protein, is present in 45%–60% of patients and acts as a key driver in melanoma. Shortly after therapy induction,… read more here.

Keywords: melanoma; melanoma derived; tumorigenicity; derived ipccs ... See more keywords

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-12001-2

Abstract: Despite the development of adjuvant therapies, glioblastoma (GBM) patients remain incurable, thus justifying the urgent need of new therapies. CDK5 plays a critical role in GBM and is a potential target for GBM. However, the… read more here.

Keywords: trim59; cdk5 dependent; nuclear translocation; tumorigenicity ... See more keywords
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Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.

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recommendations! Published in 2021 at "Nature cell biology"

DOI: 10.1038/s41556-021-00639-4

Abstract: Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However, EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that there is redundant EGFR activation. Circular RNAs are covalently closed RNA transcripts… read more here.

Keywords: egfr signalling; rna; cad; activation ... See more keywords

Assessment of molecular modulation by multifrequency electromagnetic pulses to preferably eradicate tumorigenic cells

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-81171-x

Abstract: Physics methods of cancer therapy are extensively used in clinical practice, but they are invasive and often confront undesired side effects. A fully new equipment that allows sustained emission of intense and time-controlled non-ionizing multifrequency… read more here.

Keywords: tumorigenicity; multifrequency electromagnetic; tumorigenic cells; cell ... See more keywords

PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes

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recommendations! Published in 2017 at "Carcinogenesis"

DOI: 10.1093/carcin/bgx062

Abstract: Breast cancer (BC) is a highly heterogeneous disease, both at the pathological and molecular level, and several chromatin-associated proteins play crucial roles in BC initiation and progression. Here, we demonstrate the role of PSIP1 (PC4… read more here.

Keywords: psip1 p75; p75; cell cycle; tumorigenicity ... See more keywords