PD-1 blockade in solid tumors with defects in polymerase epsilon.
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DOI: 10.1158/2159-8290.cd-21-0521
Abstract: Missense mutations in the polymerase epsilon (POLE) gene have been reported to generate proofreading defects resulting in an ultramutated genome and sensitize tumors to checkpoint blockade immunotherapy. However, many POLE mutated tumors do not respond… read more here.
Keywords: polymerase epsilon; pole; solid tumors; tumors defects ... See more keywords