Metabolism in the tumour cell and beyond.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13467
Abstract: The process of cellular transformation encompasses the acquisition of key and distinctive features, commonly known as hallmarks of cancer. These hallmarks are supported by tumour-intrinsic molecular alterations as well as changes in the microenvironment. Cellular… read more here.
Keywords: metabolism; tumour cell; metabolism tumour; biology ... See more keywords
The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32045
Abstract: Tumour cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5,… read more here.
Keywords: mct; tumour cell; tumour microenvironment; colorectal cancer ... See more keywords
Tumour cell surface antigen targeted therapies in B-cell lymphomas: Beyond rituximab.
Sign Up to like & getrecommendations! Published in 2017 at "Blood reviews"
DOI: 10.1016/j.blre.2016.08.001
Abstract: Recent proliferation of novel targeted therapies in lymphoma has been substantial. B-cell receptor pathway inhibitors and immune checkpoint inhibitors have been a major focus, however significant advances in monoclonal antibodies (MoAbs) which directly target malignant… read more here.
Keywords: tumour cell; cell surface; cell; surface antigen ... See more keywords
Visualisation of tumour cells in bone in vivo at single-cell resolution.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116113
Abstract: The skeleton is a common site for the establishment of distant metastases. Once cancers occupy bone, the prognosis is poor as disease recurrence and visceral spread is imminent. Understanding the pathways and cellular interactions, which… read more here.
Keywords: single cell; tumour cell; tumour cells; bone ... See more keywords
Circulating tumour cell PD-L1 test for head and neck cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2017.10.011
Abstract: Immune checkpoint inhibitors have gained traction over the last few years in the treatment of metastatic/recurrent head and neck squamous cell carcinoma (HNSCC) patients. Monoclonal antibodies that block the programmed death 1 (PD-1) receptor and… read more here.
Keywords: tumour cell; cell; circulating tumour; head neck ... See more keywords
Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14041
Abstract: Tumour cells secrete exosomes that are involved in the remodelling of the tumour–stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion… read more here.
Keywords: tumour cell; pyruvate kinase; exosome release; cell ... See more keywords
Cooperative tumour cell membrane targeted phototherapy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15880
Abstract: The targeted delivery of therapeutics using antibodies or nanomaterials has improved the precision and safety of cancer therapy. However, the paucity and heterogeneity of identified molecular targets within tumours have resulted in poor and uneven… read more here.
Keywords: tumour cell; cell; cell membrane; membrane targeted ... See more keywords
Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-79893-9
Abstract: The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell… read more here.
Keywords: tumour cell; synthesis tumour; uptake studies; studies gadolinium ... See more keywords
Subtypes of tumour cell-derived small extracellular vesicles having differently externalized phosphatidylserine
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Extracellular Vesicles"
DOI: 10.1080/20013078.2019.1579541
Abstract: ABSTRACT Phosphatidylserine (PS) has skewed distributions in the plasma membrane and is preferentially located in the inner leaflet of normal cells. Tumour cells, however, expose PS at the outer leaflet of cell surfaces, thereby potentially… read more here.
Keywords: extracellular vesicles; tumour cell; subtypes tumour; phosphatidylserine ... See more keywords
THER-03. IN VITRO EVALUATION OF THE EFFECT OF CANNABIDIOL ON PAEDIATRIC BRAIN TUMOUR CELL LINES USING A PULSED TREATMENT REGIME
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.853
Abstract: Abstract Paediatric brain tumours are the second most common cancer after haematological malignancies. Intermittent dosing regimens are typical for chemotherapy drugs in order to avoid excessive damage to organs and avoid the onset of late… read more here.
Keywords: tumour cell; cell; cell lines; brain tumour ... See more keywords
A Bayesian network meta‐analysis of comparison of cancer therapeutic vaccines for melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.17437
Abstract: Several approaches to active immunotherapy for melanoma, including peptide‐based vaccines (PVs), autologous tumour cell vaccines (TCVs), allogeneic TCVs and autologous dendritic cell vaccines (DCVs), have been investigated in clinical trials. However, comprehensive evidence comparing these… read more here.
Keywords: tumour cell; analysis; cell vaccines; network meta ... See more keywords