Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection
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DOI: 10.1186/s12859-017-1753-2
Abstract: BackgroundEpigenetic heterogeneity within a tumour can play an important role in tumour evolution and the emergence of resistance to treatment. It is increasingly recognised that the study of DNA methylation (DNAm) patterns along the genome… read more here.
Keywords: quantification tumour; heterogeneity; tumour; tumour evolution ... See more keywords
Learning mutational graphs of individual tumour evolution from single-cell and multi-region sequencing data
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DOI: 10.1186/s12859-019-2795-4
Abstract: BackgroundA large number of algorithms is being developed to reconstruct evolutionary models of individual tumours from genome sequencing data. Most methods can analyze multiple samples collected either through bulk multi-region sequencing experiments or the sequencing… read more here.
Keywords: single cell; sequencing data; multi region; tumour evolution ... See more keywords