MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.58
Abstract: Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway. These proteins, which coactivate LArge Tumour Suppressor homologue kinases, are also tumour suppressors. To investigate MOB1A/B’s roles in normal physiology and lung… read more here.
Keywords: nkx2 axis; mob1 yap1; taz nkx2; tumour formation ... See more keywords
Identification of genes that promote PI3K pathway activation and prostate tumour formation
Sign Up to like & getrecommendations! Published in 2024 at "Oncogene"
DOI: 10.1038/s41388-024-03028-x
Abstract: We have performed a functional in vivo mutagenesis screen to identify genes that, when altered, cooperate with a heterozygous Pten mutation to promote prostate tumour formation. Two genes, Bzw2 and Eif5a2, which have been implicated… read more here.
Keywords: genes promote; tumour formation; formation; prostate tumour ... See more keywords