HSF1 activates the FOXO3a–ΔNp63α–CDK4 axis to promote head and neck squamous cell carcinoma cell proliferation and tumour growth
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14588
Abstract: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers worldwide. Heat shock factor 1 (HSF1) is a conserved transcriptional factor that plays a critical role in maintaining cellular proteostasis. However,… read more here.
Keywords: cell; hsf1; tumour growth; head neck ... See more keywords
Exposure‐tumour growth inhibition modelling of brigimadlin using phase I solid tumour data to support phase II dose selection
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Clinical Pharmacology"
DOI: 10.1002/bcp.70031
Abstract: Brigimadlin (BI 907828) is a potent, oral MDM2‐p53 antagonist under clinical investigation for the treatment of advanced solid tumours. A brigimadlin exposure–tumour growth inhibition (E‐TGI) model was developed to support the recommended phase II dose… read more here.
Keywords: brigimadlin; tumour growth; growth inhibition; exposure tumour ... See more keywords
Endothelial extracellular vesicles promote tumour growth by tumour‐associated macrophage reprogramming
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12228
Abstract: Abstract Tumour‐derived extracellular vesicles (EVs) participate in tumour progression by deregulating various physiological processes including angiogenesis and inflammation. Here we report that EVs released by endothelial cells in a mammary tumour environment participate in the… read more here.
Keywords: tumour growth; extracellular vesicles; tumour; vesicles promote ... See more keywords
Cancer‐Specific RNA Modifications in Tumour‐Derived Extracellular Vesicles Promote Tumour Growth
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70083
Abstract: ABSTRACT RNA modifications are crucial in cellular processes, and their dysregulation is linked to diseases like cancer. Extracellular vesicles (EVs) contain various RNAs and might be susceptible to modifications, but detecting these modifications has been… read more here.
Keywords: extracellular vesicles; cancer; cancer specific; tumour growth ... See more keywords
Bayesian Calibration, Validation and Uncertainty Quantification for Predictive Modelling of Tumour Growth: A Tutorial
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-017-0258-5
Abstract: In this work, we present a pedagogical tumour growth example, in which we apply calibration and validation techniques to an uncertain, Gompertzian model of tumour spheroid growth. The key contribution of this article is the… read more here.
Keywords: model; growth; tumour growth; calibration validation ... See more keywords
Dual roles of tumour cells-derived matrix metalloproteinase 2 on brain tumour growth and invasion
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Cancer"
DOI: 10.1038/bjc.2017.362
Abstract: Background:A previous study on a murine astrocytoma cell-line ALTS1C1 showed a highly invasive pattern similar to clinical anaplastic astrocytoma in vivo. This cell-line also expressed a high level of matrix metalloproteinase 2 (MMP2). This study… read more here.
Keywords: roles tumour; tumour growth; brain tumour; matrix metalloproteinase ... See more keywords
The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms13930
Abstract: Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has… read more here.
Keywords: hepatocellular carcinoma; model; tumour growth; immunoreceptor nkg2d ... See more keywords
SERIneALanine Killer: SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00401-6
Abstract: In a recent article in Nature, Muthusami et al. highlight the promiscuity of serine palmitoyltransferase (SPT) for non-essential amino acids under low serine conditions, illustrating a previously unappreciated mechanism for inhibition of tumour growth— increased… read more here.
Keywords: alanine; muthusami; tumour growth; serine ... See more keywords
Vessel co-option and angiotropic extravascular migratory metastasis: a continuum of tumour growth and spread?
Sign Up to like & getrecommendations! Published in 2022 at "British journal of cancer"
DOI: 10.1038/s41416-021-01686-2
Abstract: Two fields of cancer research have emerged dealing with the biology of tumour cells localised to the abluminal vascular surface: vessel co-option (VCo), a non-angiogenic mode of tumour growth and angiotropic extravascular migratory metastasis (EVMM),… read more here.
Keywords: cancer; tumour growth; angiotropic extravascular; vessel option ... See more keywords
Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16618-6
Abstract: The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown. We show that… read more here.
Keywords: pericyte fak; fak; tumour growth; angiogenesis ... See more keywords
Aspartate is an endogenous metabolic limitation for tumour growth
Sign Up to like & getrecommendations! Published in 2018 at "Nature cell biology"
DOI: 10.1038/s41556-018-0125-0
Abstract: Defining the metabolic limitations of tumour growth will help to develop cancer therapies1. Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that a metabolic limitation may restrict cell proliferation in vivo.… read more here.
Keywords: metabolic limitation; cell; tumour growth; cancer ... See more keywords