Treatment-driven tumour heterogeneity and drug resistance: Lessons from solid tumours.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2022.102340
Abstract: Molecular heterogeneity characterizes tumours' evolution and adaptation and, because of its dynamics and continuous changes under external pressure, it is one of the major causes of drug resistance, contributing to therapy failure. Several studies reported… read more here.
Keywords: tumour heterogeneity; drug; resistance; treatment ... See more keywords
Seeing whole-tumour heterogeneity
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-017-0150-5
Abstract: Light-sheet microscopy reveals 3D tumour heterogeneity in optically cleared paraffin-embedded tumour samples. read more here.
Keywords: tumour heterogeneity; microscopy; heterogeneity; whole tumour ... See more keywords
EPEN-43. TARGETING INTRA-TUMOUR HETEROGENEITY IN PAEDIATRIC EPENDYMOMA: AN INTEGRATED OMICS STUDY TOWARDS PATIENT-TAILORED THERAPY
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.177
Abstract: Abstract Ependymoma (EPN) is the second most common malignant paediatric brain tumour, which despite extensive genomic sequencing, no novel therapeutic options have been discovered. Multi-omics are anticipated to reveal dysregulated pathways that may be predictive… read more here.
Keywords: tumour heterogeneity; patient tailored; ependymoma; tailored therapy ... See more keywords
The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome
Sign Up to like & getrecommendations! Published in 2017 at "BMC Medicine"
DOI: 10.1186/s12916-017-0900-y
Abstract: BackgroundThe advent of rapid and inexpensive sequencing technology allows scientists to decipher heterogeneity within primary tumours, between primary and metastatic sites, and between metastases. Charting the evolutionary history of individual tumours has revealed drivers of… read more here.
Keywords: tumour heterogeneity; role tumour; clonal cooperativity; heterogeneity ... See more keywords
18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy
Sign Up to like & getrecommendations! Published in 2020 at "EJNMMI Research"
DOI: 10.1186/s13550-020-00728-9
Abstract: Background Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need… read more here.
Keywords: tumour heterogeneity; adt; prostate cancer; fluciclovine ... See more keywords
Deciphering Tumour Heterogeneity: From Tissue to Liquid Biopsy
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DOI: 10.3390/cancers14061384
Abstract: Simple Summary Most malignant tumours are highly heterogeneous at molecular and phenotypic levels. Tumour variability poses challenges for the management of patients, as it arises between patients and even evolves in space and time within… read more here.
Keywords: diversity; time; cancer; tumour heterogeneity ... See more keywords
Heterogeneity in Melanoma
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DOI: 10.3390/cancers14123030
Abstract: Simple Summary Tumour heterogeneity is a phenomenon where the cancer cells evolve diversely over the course of the disease. As a result of the evolution, the cancer cells can be found to be genetically, epigenetically… read more here.
Keywords: heterogeneity; tumour heterogeneity; heterogeneity melanoma; evolution ... See more keywords
Tumour Heterogeneity and the Consequent Practical Challenges in the Management of Gastroenteropancreatic Neuroendocrine Neoplasms
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061861
Abstract: Simple Summary Neuroendocrine tumours, recently reclassified as neuroendocrine neoplasms (NENs), are a heterogeneous group of tumours with variability in their disease course and outcome. Complex mechanisms involving spatial and temporal changes in tumour biology affect… read more here.
Keywords: heterogeneity; tumour heterogeneity; neuroendocrine neoplasms; treatment ... See more keywords