Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting.
Sign Up to like & getrecommendations! Published in 2022 at "Nature biomedical engineering"
DOI: 10.1038/s41551-021-00820-y
Abstract: Adoptive cell therapies require the recovery and expansion of highly potent tumour-infiltrating lymphocytes (TILs). However, TILs in tumours are rare and difficult to isolate efficiently, which hinders the optimization of therapeutic potency and dose. Here… read more here.
Keywords: cell sorting; immunomagnetic cell; tumour infiltrating; potent tumour ... See more keywords
Macrophage targeting: opening new possibilities for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1111/imm.12976
Abstract: Tumour‐infiltrating immune cells regulate tumour development and progression either negatively or positively. For example, cytotoxic lymphocytes (CTL) such as CD8+ T and natural killer (NK) cells can recognize and eliminate cancer cells, and thereby restrict… read more here.
Keywords: tumour infiltrating; macrophage targeting; ctl; cancer ... See more keywords
NR4A1 mediates NK‐cell dysfunction in hepatocellular carcinoma via the IFN‐γ/p‐STAT1/IRF1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13611
Abstract: Hepatocellular carcinoma (HCC) is one of the most fatal tumours worldwide and has a high recurrence rate. Nevertheless, the mechanism of HCC genesis remains partly unexplored, while the efficiency of HCC treatments remains limited. The… read more here.
Keywords: hepatocellular carcinoma; ifn stat1; dysfunction; stat1 irf1 ... See more keywords
Immune classification for the PD-L1 expression and tumour-infiltrating lymphocytes in colorectal adenocarcinoma
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DOI: 10.1186/s12885-020-6553-9
Abstract: Background Colorectal adenocarcinoma is the third most common cancer worldwide and a leading cause of cancer-related death. The recent emergence of diverse immunotherapeutic agents has made it crucial to interpret a complex tumour microenvironment intermingled… read more here.
Keywords: immune; tumour infiltrating; colorectal adenocarcinoma; infiltrating lymphocytes ... See more keywords
INTEGRATING BIOREACTOR SYSTEM TO SPEED UP TUMOUR INFILTRATING LYMPHOCYTES (TILS) IMMUNOTHERAPY COMMERCIALIZATION
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DOI: 10.22159/ijap.2020v12i4.37244
Abstract: One of the major breakthroughs on adoptive cell transfer (ACT) is autologous T cells transfer that either derived from tumour infiltrating lymphocytes (TILs) or genetically engineered T cells, which express tumour recognizing receptors. Between those… read more here.
Keywords: tumour infiltrating; lymphocytes tils; infiltrating lymphocytes; til therapy ... See more keywords
Characterization of the immune cell landscape in CRC: Clinical implications of tumour-infiltrating leukocytes in early- and late-stage CRC
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.978862
Abstract: Introduction Colorectal cancer (CRC) is the third leading cause of cancer-related deaths globally. Tumour-infiltrating leukocytes play an important role in cancers, including CRC. We therefore sought to characterize the impact of tumour-infiltrating leukocytes on CRC… read more here.
Keywords: immune cell; cell; stage crc; tumour infiltrating ... See more keywords
Clinical Significance of Tumour-Infiltrating B Lymphocytes (TIL-Bs) in Breast Cancer: A Systematic Literature Review
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DOI: 10.3390/cancers15041164
Abstract: Simple Summary Breast cancer is the most frequently diagnosed cancer among women worldwide. Although there have been significant advances in the past decade in our understanding of breast cancer biology and the choice of treatment,… read more here.
Keywords: clinical significance; breast cancer; medicine; cancer ... See more keywords
Tumour infiltrating lymphocytes in colorectal cancers- correlation with tumour biology and clinical outcome: A cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "JPMA. The Journal of the Pakistan Medical Association"
DOI: 10.47391/jpma.4363
Abstract: OBJECTIVE To evaluate the pattern of tumour infiltrating lymphocytes in colorectal cancers, and to correlate them with nuclear protein Ki67, vascular endothelial growth factor and clinical outcome. METHODS The retrospective study was conducted at the… read more here.
Keywords: colorectal cancers; infiltrating lymphocytes; lymphocytes colorectal; biology ... See more keywords