Associating transcriptomics data with inflammatory markers to understand tumour microenvironment in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4941
Abstract: Liver cancer is the fourth leading cause of cancer‐related death globally which is estimated to reach more than 1 million deaths a year by 2030. Among liver cancer types, hepatocellular carcinoma (HCC) accounts for approximately… read more here.
Keywords: tumour microenvironment; hepatocellular carcinoma; associating transcriptomics; cancer ... See more keywords
The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32045
Abstract: Tumour cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5,… read more here.
Keywords: mct; tumour cell; tumour microenvironment; colorectal cancer ... See more keywords
Beyond the tumour microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32343
Abstract: In contrast to the once dominant tumour‐centric view of cancer, increasing attention is now being paid to the tumour microenvironment (TME), generally understood as the elements spatially located in the vicinity of the tumour. Thinking… read more here.
Keywords: cancer; tumour microenvironment; centric view; beyond tumour ... See more keywords
Targeting DNA topoisomerase IIα (TOP2A) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs (uHAPs)
Sign Up to like & getrecommendations! Published in 2022 at "Iubmb Life"
DOI: 10.1002/iub.2619
Abstract: The hypoxic tumour microenvironment (hTME), arising from inadequate and chaotic vascularity, can present a major obstacle for the treatment of solid tumours. Hypoxic tumour cells compromise responses to treatment since they can generate resistance to… read more here.
Keywords: tumour microenvironment; unidirectional hypoxia; top2a; activated prodrugs ... See more keywords
Effects of Exercise on the Tumour Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-35727-6_3
Abstract: Epidemiological evidence suggests that exercise improves survival in cancer patients. However, much is still unknown regarding the mechanisms of this positive survival effect and there are indications that exercise may not be universally beneficial for… read more here.
Keywords: tumour microenvironment; exercise tumour; tme; effects exercise ... See more keywords
The Role of Glypican-1 in the Tumour Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-40146-7_8
Abstract: Glypican-1 (GPC-1) is a cell surface heparan sulphate proteoglycan that is critical during normal development, but which is not required for normal homoeostasis in the adult. It is, however, overexpressed in a variety of solid… read more here.
Keywords: role; tumour microenvironment; biology; gpc ... See more keywords
Viral Hepatitides, Inflammation and Tumour Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-44518-8_3
Abstract: In this chapter, we discuss the role of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the establishment of hepatocellular carcinoma (HCC), highlighting the key role of the multiple, non-mutually exclusive, pathways… read more here.
Keywords: inflammation tumour; viral hepatitides; biology; role ... See more keywords
Lysophospholipid Signalling and the Tumour Microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-47189-7_8
Abstract: Homeostasis is the key to survival. This is as true for the tumour cell as it is for the normal host cell. Tumour cells and normal host cells constantly interact with each other, and the… read more here.
Keywords: microenvironment; tumour cells; host; signalling molecules ... See more keywords
Tight Interplay Between Therapeutic Monoclonal Antibodies and the Tumour Microenvironment in Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-50224-9_9
Abstract: Therapeutic monoclonal antibodies (mAb) have changed the landscape of cancer therapy. With advances in the understanding of tumour biology and its microenvironment, different categories of mAbs have been developed; a first category is directed against… read more here.
Keywords: monoclonal antibodies; therapeutic monoclonal; biology; tumour microenvironment ... See more keywords
Metabolic profiles of regulatory T cells in the tumour microenvironment
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02881-z
Abstract: Metabolic reprogramming of cancer cells generates a tumour microenvironment (TME) characterised by nutrient restriction, hypoxia, acidity and oxidative stress. While these conditions are unfavourable for infiltrating effector T cells, accumulating evidence suggests that regulatory T… read more here.
Keywords: metabolic profiles; profiles regulatory; cells tumour; regulatory cells ... See more keywords
The role of PET in imaging of the tumour microenvironment and response to immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical radiology"
DOI: 10.1016/j.crad.2021.08.004
Abstract: Positron emission tomography (PET) is an exquisitely sensitive molecular imaging technique with broad utility in cancer diagnosis and monitoring. Many ligands labelled with positron-emitting isotopes have been developed that are of interest in the field… read more here.
Keywords: pet; response; role pet; cancer ... See more keywords