Quantitative PET imaging of PD-L1 expression in xenograft and syngeneic tumour models using a site-specifically labelled PD-L1 antibody
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04646-4
Abstract: Purpose Despite remarkable clinical responses and prolonged survival across several cancers, not all patients benefit from PD-1/PD-L1 immune checkpoint blockade. Accordingly, assessment of tumour PD-L1 expression by immunohistochemistry (IHC) is increasingly applied to guide patient… read more here.
Keywords: tumour models; pet imaging; site specifically; dfo 6e11 ... See more keywords
Patient-derived tumour models for personalized therapeutics in urological cancers
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Urology"
DOI: 10.1038/s41585-020-00389-2
Abstract: Preclinical knowledge of dysregulated pathways and potential biomarkers for urological cancers has undergone limited translation into the clinic. Moreover, the low approval rate of new anticancer drugs and the heterogeneous drug responses in patients indicate… read more here.
Keywords: derived tumour; tumour models; patient derived; oncology ... See more keywords
Optimization of cell lines as tumour models by integrating multi-omics data
Sign Up to like & getrecommendations! Published in 2017 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbw082
Abstract: Cell lines are widely used as in vitro models of tumorigenesis. However, an increasing number of researchers have found that cell lines differ from their sourced tumour samples after long-term cell culture. The application of… read more here.
Keywords: tumour models; optimization cell; cell lines; lines tumour ... See more keywords