A predictive model for distinguishing radiation necrosis from tumour progression after gamma knife radiosurgery based on radiomic features from MR images
Sign Up to like & getrecommendations! Published in 2017 at "European Radiology"
DOI: 10.1007/s00330-017-5154-8
Abstract: ObjectivesTo develop a model using radiomic features extracted from MR images to distinguish radiation necrosis from tumour progression in brain metastases after Gamma Knife radiosurgery.MethodsWe retrospectively identified 87 patients with pathologically confirmed necrosis (24 lesions)… read more here.
Keywords: radiomic features; tumour progression; radiation necrosis; necrosis tumour ... See more keywords
Anaesthesia as an influence in tumour progression
Sign Up to like & getrecommendations! Published in 2021 at "Langenbeck's Archives of Surgery"
DOI: 10.1007/s00423-021-02078-z
Abstract: Tumour growth and the formation of metastases are essential elements in the progression of cancer. The centre of treatment is the surgical resection of primary solid tumours. But even if the tumour can be removed… read more here.
Keywords: tumour cells; anaesthesia influence; tumour progression; progression ... See more keywords
The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression
Sign Up to like & getrecommendations! Published in 2017 at "Purinergic Signalling"
DOI: 10.1007/s11302-017-9593-0
Abstract: Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised. P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular C terminus. Low concentrations of ATP open cation… read more here.
Keywords: p2x7 receptors; tumour progression; potential p2x7; inflammation ... See more keywords
Suppression of angiogenesis and tumour progression by combretastatin and derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.06.032
Abstract: The search for small molecule inhibitors has gained prominence with the recognition of their inherent advantage for cancer therapy. Combretastatin is a naturally occurring small stilbenoid. By virtue of the ability to bind to tubulin… read more here.
Keywords: angiogenesis tumour; suppression angiogenesis; combretastatin derivatives; tumour progression ... See more keywords
ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02017-8
Abstract: ISG15 is an ubiquitin-like modifier that is associated with reduced survival rates in breast cancer patients. The mechanism by which ISG15 achieves this however remains elusive. We demonstrate that modification of Rab GDP-Dissociation Inhibitor Beta… read more here.
Keywords: basal breast; isgylation; egfr recycling; tumour progression ... See more keywords
Age-induced accumulation of methylmalonic acid promotes tumour progression
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2630-0
Abstract: The risk of cancer and associated mortality increases substantially in humans from the age of 65 years onwards 1 – 6 . Nonetheless, our understanding of the complex relationship between age and cancer is still in… read more here.
Keywords: age; methylmalonic acid; promotes tumour; tumour progression ... See more keywords
Machine learning imaging applications in the differentiation of true tumour progression from treatment‐related effects in brain tumours: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Imaging and Radiation Oncology"
DOI: 10.1111/1754-9485.13436
Abstract: Chemotherapy and radiotherapy can produce treatment‐related effects, which may mimic tumour progression. Advances in Artificial Intelligence (AI) offer the potential to provide a more consistent approach of diagnosis with improved accuracy. The aim of this… read more here.
Keywords: related effects; treatment related; tumour progression; machine learning ... See more keywords
Disabled 2 (Dab2) Regulates Tumour Progression in Skin Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Experimental Dermatology"
DOI: 10.1111/exd.70009
Abstract: Dab2 is an endocytic adaptor protein involved in various physiological processes and signaling pathways. Dab2 is deregulated in various cancers; however, its role in skin squamous cell carcinoma ( SCC) has not been elucidated yet.… read more here.
Keywords: tumour progression; dab2; cell; squamous cell ... See more keywords
Glycans in melanoma: Drivers of tumour progression but sweet targets to exploit for immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Immunology"
DOI: 10.1111/imm.13801
Abstract: Aberrant glycosylation recently emerged as an unmissable hallmark of cancer progression in many cancers. In melanoma, there is growing evidence that the tumour ‘glycocode’ plays a major role in promoting cell proliferation, invasion, migration, but… read more here.
Keywords: tumour progression; progression; glycans melanoma; anti tumour ... See more keywords
Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Immunology"
DOI: 10.1111/imm.13832
Abstract: The adverse effects observed in some cancer patients treated with erythropoiesis‐stimulating agents such as erythropoietin (EPO) might be due to the latter's well‐known immunosuppressive functions. Here, we used a mouse model of syngeneic triple‐negative breast… read more here.
Keywords: cancer; cd39; tumour progression; negative breast ... See more keywords
Newly discovered mechanisms that mediate tumorigenesis and tumour progression: circRNA-encoded proteins.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17751
Abstract: Proteins produced by cap-independent translation mediated by an internal ribosome entry site (IRES) in circular RNAs (circRNAs) play important roles in tumour progression. To date, numerous studies have been performed on circRNAs and the proteins… read more here.
Keywords: circrna encoded; tumour progression; newly discovered; encoded proteins ... See more keywords