TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis
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DOI: 10.1038/s41467-025-63754-y
Abstract: Alterations in 3D chromatin conformation may disrupt the interplay between promoters and distal enhancers. How gene regulatory circuits are reshaped during ionizing radiation-induced tumorigenesis remains unclear, and little is known about the mediators that drive… read more here.
Keywords: radiation induced; chromatin; specific chromatin; induced tumorigenesis ... See more keywords
PO-379 Novel tumour specific miRNA expressed in classical hodgkin lymphoma cell lines
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DOI: 10.1136/esmoopen-2018-eacr25.407
Abstract: Introduction MiRNAs are short non coding RNAs involved in post-transcriptional regulation of gene expression that can acquire oncogenic properties in consequence of overexpression or mutations. Tumour genomes undergo global demethylation that triggers genetic instability and… read more here.
Keywords: hodgkin lymphoma; classical hodgkin; cell lines; tumour specific ... See more keywords
Abstract A060: Identification of tumour-specific variants from pleural effusion cell-free DNA as diagnostic markers of cancers affecting the lungs
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DOI: 10.1158/1557-3265.liqbiop24-a060
Abstract: Background: Pleural mesothelioma (PM) can be difficult to diagnose due to a combination of the growth pattern of the tumour, the invasive nature of the biopsy procedure and the frailty of the patient. Some patients… read more here.
Keywords: free dna; tumour; tumour specific; cell free ... See more keywords
Neutrophil-To-Lymphocyte and Platelet-To-Lymphocyte Ratios as Prognostic Markers of Survival in Patients with Head and Neck Tumours—Results of a Retrospective Multicentric Study
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DOI: 10.3390/ijerph17051742
Abstract: Background: The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) may be useful for drawing conclusions about the survival of head and neck squamous cell carcinoma (HNSCC) patients. Methods: Clinical data of 156 patients managed… read more here.
Keywords: lymphocyte platelet; platelet lymphocyte; neutrophil lymphocyte; tumour specific ... See more keywords