Tumour-stroma ratio is a valuable prognostic factor for oral tongue squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Oral diseases"
DOI: 10.1111/odi.14013
Abstract: OBJECTIVE The objectives of this study were to estimate the prognostic value of the tumour-stroma ratio (TSR) and tumour budding (TB) in oral tongue squamous cell carcinoma (OTSCC) and to establish a reliable model to… read more here.
Keywords: risk; oral tongue; stroma ratio; tumour stroma ... See more keywords
Immunosuppressive βig-h3 links tumour stroma and dysfunctional T cells in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "Gut"
DOI: 10.1136/gutjnl-2018-317735
Abstract: Recent FDA approval of anti-PD-1 antibody pembrolizumab as a site-agnostic therapy for mismatch repair (MMR)–deficient solid tumours has highlighted the importance of CD8+ T cell responses and the potential of immunotherapy, even in tumour entities that are… read more here.
Keywords: immunosuppressive links; stroma dysfunctional; dysfunctional cells; tumour stroma ... See more keywords
Expression of Potential Dermal Progenitor Cell Markers in the Tumour and Stroma of Skin Adnexal Malignant and Benign Tumours
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells International"
DOI: 10.1155/2019/9320701
Abstract: Stem cells are multipotent cells that maintain the skin epidermis including skin appendages such as hair follicle, sebaceous glands, and sweat glands. There is evidence that reciprocal signalling between the epidermis and the dermis plays… read more here.
Keywords: tumour stroma; stroma skin; skin; dermal progenitor ... See more keywords
Multiscalar cellular automaton simulates in-vivo tumour-stroma patterns calibrated from in-vitro assay data
Sign Up to like & getrecommendations! Published in 2017 at "BMC Medical Informatics and Decision Making"
DOI: 10.1186/s12911-017-0461-1
Abstract: BackgroundThe tumour stroma -or tumour microenvironment- is an important constituent of solid cancers and it is thought to be one of the main obstacles to quantitative translation of drug activity between the preclinical and clinical… read more here.
Keywords: tumour stroma; stroma; model; multiscalar cellular ... See more keywords
Bioengineering of a tumour-stroma 3D-tumouroid co-culture model of hypopharyngeal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Biology Open"
DOI: 10.1242/bio.059949
Abstract: ABSTRACT Head and neck cancer (HNC) differs at anatomical sites and hypopharyngeal cancer (HPC) is a type of HNC. The non-surgical treatment option for advanced cases of HPC is radiotherapy (RT) with or without chemotherapy… read more here.
Keywords: culture; tumouroid culture; tumour stroma; model ... See more keywords
Epigenetic Mechanisms beyond Tumour–Stroma Crosstalk
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13040914
Abstract: Simple Summary In this review article, we will deepen the topic of cancer cell communication with the surrounding non-cancerous cells. In particular, the non-mutational events that modified gene expression, namely “epigenetics”, involved in cell–cell interaction… read more here.
Keywords: cancer; epigenetic mechanisms; stroma crosstalk; tumour stroma ... See more keywords