Gasdermin: a novel therapeutic target for tumour treatment by activating anti-tumour immunity
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0180-4
Abstract: A very recent study by Zhang et al. published in Nature demonstrates that gasdermin E (GSDME, also known as DFNA5) is a tumour suppressor by activating caspaseindependent pyroptosis to enhance anti-tumour immunity. In the meantime,… read more here.
Keywords: immunity; pyroptosis; gsdme; tumour suppression ... See more keywords
Tumour suppression by targeted intravenous non-viral CRISPRa using dendritic polymers††Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc01432b
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc01432b
Abstract: This article demonstrates a fully synthetic strategy enabling CRISPR-mediated activation of tumour suppressor genes in vivo to reduce tumour burden. read more here.
Keywords: non viral; viral crispra; suppression targeted; intravenous non ... See more keywords
Understanding p53 tumour suppressor network
Sign Up to like & getrecommendations! Published in 2021 at "Biology Direct"
DOI: 10.1186/s13062-021-00298-3
Abstract: The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulation of several cellular functions, including cell cycle progression and cell death in response to genotoxic stress. In the… read more here.
Keywords: tumour suppressor; tumour suppression; suppressor network; p53 ... See more keywords