Tumour suppressor p53 inhibits hepatitis C virus replication by inducing E6AP‐mediated proteasomal degradation of the viral core protein
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14461
Abstract: The tumour suppressor p53 has been implicated in the host defence system against hepatitis C virus (HCV) infection, although the detailed mechanism remains unknown. Here, we found that p53 inhibits HCV replication by downregulating HCV… read more here.
Keywords: core; suppressor p53; p53; hcv core ... See more keywords
Downstream of the HOX genes: Explaining conflicting tumour suppressor and oncogenic functions in cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33949
Abstract: The HOX genes are a highly conserved group of transcription factors that have key roles in early development, but which are also highly expressed in most cancers. Many studies have found strong associative relationships between… read more here.
Keywords: tumour suppressor; hox genes; cancer; hox ... See more keywords
Transcriptomic and functional studies reveal miR-431-5p as a tumour suppressor in pancreatic ductal adenocarcinoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146346
Abstract: The lactate receptor HCAR1 (hydroxycarboxylic acid receptor 1) is highly expressed in pancreatic ductal adenocarcinoma (PDAC), where it regulates lactate transport between the cancer cells. Little is known about the underlying cause of high HCAR1… read more here.
Keywords: hcar1; pancreatic ductal; mir 431; tumour suppressor ... See more keywords
Rapid testing of candidate oncogenes and tumour suppressor genes in signal transduction and neoplastic transformation.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2021.100841
Abstract: The COSMIC database (version 94) lists 576 genes in the Cancer Gene Census which have a defined function as drivers of malignancy (oncogenes) or as tumour suppressors (Tier 1). In addition, there are 147 genes… read more here.
Keywords: rapid testing; oncogenes tumour; neoplastic transformation; transformation ... See more keywords
LACTB is a tumour suppressor that modulates lipid metabolism and cell state
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21408
Abstract: Post-mitotic, differentiated cells exhibit a variety of characteristics that contrast with those of actively growing neoplastic cells, such as the expression of cell-cycle inhibitors and differentiation factors. We hypothesized that the gene expression profiles of… read more here.
Keywords: cell; lipid metabolism; tumour suppressor; tumour ... See more keywords
Notch as a tumour suppressor
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cancer"
DOI: 10.1038/nrc.2016.145
Abstract: The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation… read more here.
Keywords: notch signalling; tumour suppressor; tumour; notch tumour ... See more keywords
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22319-5
Abstract: The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in… read more here.
Keywords: fbw7; tumour suppressor; proteasomal degradation; suppressor fbw7 ... See more keywords
A pan-cancer analysis reveals nonstop extension mutations causing SMAD4 tumour suppressor degradation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-0551-7
Abstract: Nonstop or stop-loss mutations convert a stop into a sense codon, resulting in translation into the 3′ untranslated region as a nonstop extension mutation to the next in-frame stop codon or as a readthrough mutation… read more here.
Keywords: cancer; nonstop extension; extension; tumour suppressor ... See more keywords
TET1 exerts its tumour suppressor function by regulating autophagy in glioma cells
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20160523
Abstract: DNA methylation and demethylation play a critical role in the regulation of the molecular pathogenesis of gliomas. Tet methylcytosine dioxygenase 1 (TET1) catalyses the sequential oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine, (5hmC) leading to eventual… read more here.
Keywords: glioma; u251 cells; tumour suppressor; expression tet1 ... See more keywords
MDM2’s dual mRNA binding domains co-ordinate its oncogenic and tumour suppressor activities
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa431
Abstract: Abstract Cell growth requires a high level of protein synthesis and oncogenic pathways stimulate cell proliferation and ribosome biogenesis. Less is known about how cells respond to dysfunctional mRNA translation and how this feeds back… read more here.
Keywords: e2f1 mrna; mrna binding; tumour suppressor; translation ... See more keywords
The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo
Sign Up to like & getrecommendations! Published in 2021 at "Open Biology"
DOI: 10.1098/rsob.200408
Abstract: Linker histones H1 are essential chromatin components that exist as multiple developmentally regulated variants. In metazoans, specific H1s are expressed during germline development in a tightly regulated manner. However, the mechanisms governing their stage-dependent expression… read more here.
Keywords: female germline; dbigh1; tumour suppressor; linker histone ... See more keywords