Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
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DOI: 10.1038/s41467-019-09474-6
Abstract: Large protein machines are tightly regulated through allosteric communication channels. Here we demonstrate the involvement of ultrafast conformational dynamics in allosteric regulation of ClpB, a hexameric AAA+ machine that rescues aggregated proteins. Each subunit of ClpB… read more here.
Keywords: machine; tunable microsecond; clpb; dynamics allosteric ... See more keywords