Tuning of Conformational Dynamics Through Evolution-Based Design Modulates the Catalytic Adaptability of an Extremophilic Kinase
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DOI: 10.1021/acscatal.0c01300
Abstract: Conformational flexibility plays a critical role in enzyme function and is a key aspect in transitions from an open to a closed state induced by substrate binding and product release. Psychrophilic... read more here.
Keywords: tuning conformational; conformational dynamics; design modulates; evolution based ... See more keywords
Controlling protein function by fine-tuning conformational flexibility
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DOI: 10.7554/elife.57180
Abstract: In a living cell, protein function is regulated in several ways, including post-translational modifications (PTMs), protein-protein interaction, or by the global environment (e.g. crowding or phase separation). While site-specific PTMs act very locally on the… read more here.
Keywords: protein function; controlling protein; fine tuning; tuning conformational ... See more keywords