Physiochemical Tuning of Potent Escherichia coli Anti‐Adhesives by Microencapsulation and Methylene Homologation
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DOI: 10.1002/cmdc.201700061
Abstract: Thiazolylaminomannosides (TazMan) are FimH antagonists with anti‐adhesive potential against adherent‐invasive Escherichia coli (AIEC) promoting gut inflammation in patients with Crohn's disease. The lead TazMan is highly potent in vitro, but shows limited in vivo efficiency, probably due… read more here.
Keywords: anti adhesive; tuning potent; physiochemical tuning; escherichia coli ... See more keywords