Insights into the assembly and activation of the microtubule nucleator γ-TuRC
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1896-6
Abstract: Microtubules are dynamic polymers of α- and β-tubulin and have crucial roles in cell signalling, cell migration, intracellular transport and chromosome segregation 1 . They assemble de novo from αβ-tubulin dimers in an essential process… read more here.
Keywords: microtubule nucleation; microtubule; microscopy; turc ... See more keywords
Reconstitution of the recombinant human γ-tubulin ring complex
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DOI: 10.1098/rsob.200325
Abstract: Cryo-electron microscopy recently resolved the structure of the vertebrate γ-tubulin ring complex (γ-TuRC) purified from Xenopus laevis egg extract and human cells to near-atomic resolution. These studies clarified the arrangement and stoichiometry of γ-TuRC components… read more here.
Keywords: tubulin ring; turc; ring complex; reconstitution recombinant ... See more keywords
The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.04.11.487887
Abstract: To establish the microtubule cytoskeleton, the cell must tightly regulate when and where microtubules are nucleated. This regulation involves controlling the initial nucleation template, the γ-tubulin ring complex (γTuRC). Although γTuRC is present throughout the… read more here.
Keywords: ring complex; nucleation; tubulin ring; complex turc ... See more keywords
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase.
Sign Up to like & getrecommendations! Published in 2020 at "Science advances"
DOI: 10.1126/sciadv.abe0894
Abstract: The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome. Since its discovery over two decades ago, γTuRC has evaded in vitro reconstitution and thus… read more here.
Keywords: tubulin ring; turc; ring complex; ruvbl1 ruvbl2 ... See more keywords
MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation
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DOI: 10.1242/jcs.195321
Abstract: ABSTRACT Regulation of the γ-tubulin ring complex (γTuRC) through targeting and activation restricts nucleation of microtubules to microtubule-organizing centers (MTOCs), aiding in the assembly of ordered microtubule arrays. However, the mechanistic basis of this important… read more here.
Keywords: turc assembly; mzt1; targeting activation; nucleation ... See more keywords
Molecular insight into how γ-TuRC makes microtubules.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.245464
Abstract: As one of four filament types, microtubules are a core component of the cytoskeleton and are essential for cell function. Yet how microtubules are nucleated from their building blocks, the αβ-tubulin heterodimer, has remained a… read more here.
Keywords: insight turc; molecular insight; turc; makes microtubules ... See more keywords