Abstract 621: Tumor suppressor TUSC2 immunogene therapy is synergistic with anti-PD1 in lung cancer syngeneic mouse models
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DOI: 10.1158/1538-7445.am2017-621
Abstract: TUSC2, a pro-apoptotic tumor suppressor gene whose expression is lost or decreased in most lung cancers, activates the innate immune system through initiation of broad spectrum cytokine secretion and natural killer (NK) cell activation. TUSC2… read more here.
Keywords: tumor; anti pd1; treatment; tusc2 ... See more keywords
Abstract 2603: Investigating TUSC2 for its tumor suppressive functions in glioblastoma and its role in gliomagenesis
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DOI: 10.1158/1538-7445.am2023-2603
Abstract: The role of Tumor Suppressor Candidate 2 (TUSC2) in glioblastoma (GBM) is still poorly understood. Our recent study (Cancer Letters, 2022) reported, for the first time, that TUSC2 functions as a novel tumor suppressor for… read more here.
Keywords: tumor suppressor; tusc2; role; gliomagenesis ... See more keywords
Tumor Suppressor Candidate 2 (TUSC2): Discovery, Functions, and Cancer Therapy
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DOI: 10.3390/cancers15092455
Abstract: Simple Summary Tumor Suppressor Candidate 2 (TUSC2) is an important tumor suppressor that negatively regulates cancer growth and progression in multiple cancer types. TUSC2 was first discovered as a candidate tumor suppressor gene that is… read more here.
Keywords: tusc2; cancer; candidate; tumor suppressor ... See more keywords