twas_sim, a Python-based tool for simulation and power analysis of transcriptome-wide association analysis
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad288
Abstract: Abstract Summary Genome-wide association studies (GWASs) have identified numerous genetic variants associated with complex disease risk; however, most of these associations are non-coding, complicating identifying their proximal target gene. Transcriptome-wide association studies (TWASs) have been… read more here.
Keywords: twas; wide association; transcriptome wide; analysis ... See more keywords
TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac821
Abstract: Abstract Transcriptome-wide association studies (TWASs), as a practical and prevalent approach for detecting the associations between genetically regulated genes and traits, are now leading to a better understanding of the complex mechanisms of genetic variants… read more here.
Keywords: twas atlas; twas; wide association; transcriptome wide ... See more keywords
Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009482
Abstract: Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene expression by… read more here.
Keywords: cis; complex human; level; variance ... See more keywords
Multiple-Tissue Integrative Transcriptome-Wide Association Studies Discovered New Genes Associated With Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.587243
Abstract: Genome-wide association studies (GWAS) have identified multiple causal genes associated with amyotrophic lateral sclerosis (ALS); however, the genetic architecture of ALS remains completely unknown and a large number of causal genes have yet been discovered.… read more here.
Keywords: association studies; tissue; association; genes associated ... See more keywords
Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.814303
Abstract: This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data. AS genome-wide association study (GWAS) summary data from… read more here.
Keywords: expression profiles; twas; wide association; expression ... See more keywords
Hot Corrosion Behavior of TWAS and HVOF NiCr-Based Coatings in Molten Salt
Sign Up to like & getrecommendations! Published in 2023 at "Materials"
DOI: 10.3390/ma16041712
Abstract: In order to extend the life of boilers by applying an anti-corrosion coating without the need to dismantle them, it is advisable to find coatings that can be applied using cheaper and portable techniques, such… read more here.
Keywords: based coatings; twas; nicr based; twas hvof ... See more keywords