Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF‐κB intricate network in experimentally doxorubicin‐induced cardiotoxicity in rats: The role of curcumin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22829
Abstract: Doxorubicin (DOX) is an important chemotherapeutic drug. Cardiotoxicity diminishes its clinical efficacy. We aimed to focus on the mechanism of DOX‐induced cardiotoxicity, in addition, to evaluate curcumin's protective effect against it. Twenty‐eight rats were divided… read more here.
Keywords: induced cardiotoxicity; group; cardiotoxicity; role ... See more keywords
Inhibition of suppressor of cytokine signaling 1 mediates the profibrotic effect of TWEAK/Fn14 signaling on kidney cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109615
Abstract: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) engagement with the receptor Fn14 contributes to the fibrotic process of kidney cells in systemic lupus erythematosus. Downregulation of the protein suppressor of cytokine signaling 1 (SOCS1)… read more here.
Keywords: tweak; suppressor cytokine; kidney cells; tweak fn14 ... See more keywords
TWEAK/Fn14 promotes pro‐inflammatory cytokine secretion in hepatic stellate cells via NF‐&kgr;B/STAT3 pathways
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.04.003
Abstract: HighlightsTWEAK induced the pro‐inflammatory cytokine secretion in HSCs.TWEAK activated NF‐&kgr;B and STAT3 signalling pathways in HSCs.The activation of STAT3 and NF‐&kgr;B interacted in HSCs.The pro‐inflammatory cytokine expression was p65‐ and STAT3‐dependent. Abstract Tumor necrosis factor‐like… read more here.
Keywords: kgr; inflammatory cytokine; stat3; tweak ... See more keywords
Correlation Between TWEAK Serum Level and HTLV-1 Proviral Load in HAM/TSP
Sign Up to like & getrecommendations! Published in 2024 at "Viral Immunology"
DOI: 10.1089/vim.2024.0070
Abstract: Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), the main neurological manifestation of HTLV-I, is a chronic inflammatory disease. Viral-host interaction and host genetics are two important contributors to the development of the… read more here.
Keywords: level; ham tsp; ham; proviral load ... See more keywords
TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000026
Abstract: Background and Aims: Biliary atresia (BA), a congenital cholestatic liver disease, commonly culminates in end-stage liver disease. We previously demonstrated in BA that Prominin-1 (Prom1)-expressing hepatic progenitor cells (HPCs) expand within regions of developing fibrosis,… read more here.
Keywords: prom1; tweak; fn14; ductular reactions ... See more keywords
Changes in serum TNF‐like weak inducer of apoptosis (TWEAK) levels and Psoriasis Area Severity Index (PASI) scores in plaque psoriasis patients treated with conventional versus anti‐TNF treatments
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Dermatology"
DOI: 10.1111/ijd.14646
Abstract: Psoriasis is a chronic dermatologic disease affecting 2% of the general population. Tumour necrosis factor (TNF)‐like weak inducer of apoptosis (TWEAK) is a newly defined member of the TNF family. Increased serum levels of TWEAK… read more here.
Keywords: tnf like; tweak levels; tnf; psoriasis ... See more keywords
Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.15365
Abstract: Rosacea is a chronic inflammatory skin disease of unknown pathogenesis. TWEAK and TRAIL are two cytokines thought to have a role in the pathogenesis of some inflammatory and autoimmune diseases. read more here.
Keywords: serum tweak; tweak; evaluation serum; tweak trail ... See more keywords
TWEAK/Fn14 Activation Participates in Skin Inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/6746870
Abstract: Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor—fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and… read more here.
Keywords: fn14 activation; skin inflammation; tweak fn14; tweak ... See more keywords
Lower Expression of TWEAK is Associated with Poor Survival and Dysregulate TIICs in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/8661423
Abstract: Background Lung cancer remains the leading cause of cancer death worldwide, and the most subtype is lung adenocarcinoma (LUAD). Tumor-infiltrating immune cells (TIICs) greatly impact the prognosis of LUAD. Tumor necrosis factor–like weak inducer of… read more here.
Keywords: tweak; lung adenocarcinoma; expression; poor survival ... See more keywords
Abstract A071: Characterization of TWEAK in an immunocompetent murine ovarian cancer model
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.ovarian25-a071
Abstract: High-Grade Serous Ovarian Cancer (HGSOC) is the most lethal gynecologic malignancy in the US, with 90% of patients experiencing resistance to standard-of-care chemotherapies, Carboplatin and Paclitaxel. Research implicates cancer stem-like cells (CSCs), a subpopulation of… read more here.
Keywords: cancer; cell lines; ovarian cancer; model ... See more keywords
Abstract 14801: Can Plasma Tweak Predict Coronary Slow Flow in Patients With Chronic Kidney Disease?
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.14801
Abstract: Introduction: The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is one of the inflammatory mediators contributing to the atherosclerotic process. TWEAK has been studied in chronic kidney disease (CKD) patients and it has been… read more here.
Keywords: chronic kidney; slow flow; csf; level ... See more keywords