Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01285
Abstract: The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here, we… read more here.
Keywords: twik related; channel; antinociceptive activity; related channel ... See more keywords
A9357 The genetic polymorphisms of TWIK-related acid-sensitive K+ channel-3 (TASK-3) were associated with obstructive sleep apnea in patients with hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548216.53388.81
Abstract: Objectives: TWIK-related acid-sensitive K+ channel-3 was reported to be a risk factor for OSA in animal models. The present study aimed to evaluate the relationship between human TASK-3 gene polymorphisms and obstructive sleep apnea in… read more here.
Keywords: twik related; related acid; task; hypertension ... See more keywords