Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA surgery"
DOI: 10.1001/jamasurg.2023.1560
Abstract: Importance Immediate consequences of trauma include a rapid and immense activation of the immune system, whereas long-term outcomes include premature death, physical disability, and reduced workability. Objective To investigate if moderate to severe trauma is… read more here.
Keywords: twin; trauma; mediated cancer; immune mediated ... See more keywords
Cancer in twin pairs discordant for smoking: The Nordic Twin Study of Cancer
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DOI: 10.1002/ijc.33963
Abstract: The discordant twin pair study design is powerful to control for familial confounding. We employed this approach to investigate the associations of smoking with several cancers. The NorTwinCan study combines data from the Danish, Finnish,… read more here.
Keywords: pairs discordant; twin; cancer; cancer cancer ... See more keywords
Comment on “Epigenetics in the pathogenesis of RA”
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-017-0638-9
Abstract: Dear Editors, Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects between 0.5 and 1% of individuals in the more economically developed countries [1]. The cause of the disease is yet to be determined,… read more here.
Keywords: dmrs; immunopathology; study; twin pairs ... See more keywords
Exploring human trainability: Design and rationale of Studies of Twin Responses to Understand Exercise as a Therapy (STRUETH) study
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2020.100584
Abstract: Background Exercise confers myriad health benefits and physical inactivity is a modifiable risk factor for many non-communicable chronic diseases. However, individual responsiveness to guideline-based exercise programs is idiosyncratic for health and fitness outcomes. It is… read more here.
Keywords: exercise modalities; twin pairs; exercise; human trainability ... See more keywords
Whole genome miRNA profiling revealed miR-199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies.
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DOI: 10.1016/j.placenta.2020.02.002
Abstract: INTRODUCTION Placental-related mechanism of fetal growth restriction (FGR) is still unknown. Here we aimed to profile whole-genome miRNA between selective FGR twin (sFGR-T) and normally larger co-twin (sL-T) in monochorionic (MC) twin pregnancies and to… read more here.
Keywords: mirna; mir 199a; twin pairs; sfgr ... See more keywords
Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer
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DOI: 10.1017/thg.2022.32
Abstract: Abstract DNA methylation-based age acceleration (DNAmAA) is associated with cancer, with both cancer tissue and blood showing increased DNAmAA. We aimed to investigate whether DNAmAA is associated with cancer risk within twin pairs discordant for… read more here.
Keywords: diagnosis; acceleration; age; twin pairs ... See more keywords
Genetically identical twins show comparable tau PET load and spatial distribution
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DOI: 10.1093/brain/awac004
Abstract: Abstract Tau accumulation starts during the preclinical phase of Alzheimer’s disease and is closely associated with cognitive decline. For preventive purposes, it is important to identify factors associated with tau accumulation and spread. Studying genetically… read more here.
Keywords: genetically identical; pathology; twin pairs; distribution ... See more keywords
Adverse outcomes of sick leave due to mental disorders: prospective studies of discordant twin pairs
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DOI: 10.1093/eurpub/ckz185.700
Abstract: Sick leave due to mental disorders is common. We investigated if sick leave due to mental disorders increased the risk of reoccurring sick leave, disability pension, unemployment, in- and specialized outpatient care, and mortality, using… read more here.
Keywords: due mental; risk; sick leave; twin pairs ... See more keywords
Unravelling the genetic basis of contact allergy
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DOI: 10.1111/cod.13983
Abstract: Contact allergy occurs due to cutaneous interaction with environmental allergens that result in T-cell–mediated inflammation. Exposures to allergens could, therefore, be presumed to be the sole determinant of contact allergy. However, many contact allergens are… read more here.
Keywords: development; heritability; contact allergy; contact ... See more keywords
Fetal Aneuploidy: A Comparison of Dichorionic Twins and Monochorionic Twins
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DOI: 10.1159/000479685
Abstract: Objective: To assess the clinical characteristics of fetal aneuploidy between dichorionic twins (DCT) and monochorionic twins (MCT) undergoing invasive prenatal diagnosis. Methods: Twin fetuses undergoing invasive prenatal diagnosis were enrolled in this study. All twin… read more here.
Keywords: monochorionic twins; fetal aneuploidy; aneuploidy; twin pairs ... See more keywords
Myeloproliferative Neoplasms in Danish Twins
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DOI: 10.1159/000488384
Abstract: Objective: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development… read more here.
Keywords: danish twins; concordance; twin pairs; neoplasms danish ... See more keywords