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   Articles with "twist1" as a keyword



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Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202205873

Abstract: Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo‐resistance, metastasis, and TNBC‐related death.… read more here.

Keywords: resistance metastasis; phosphorylation usp29; twist1; cdk1 ... See more keywords
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MiR‐134‐5p attenuates neuropathic pain progression through targeting Twist1

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.27486

Abstract: Neuropathic pain is a kind of chronic pain because of dysfunctions of somatosensory nerve system. Recently, many studies have demonstrated that microRNAs (miRs) play crucial roles in neuropathic pain development. This study was designed to… read more here.

Keywords: pain progression; mir 134; twist1; neuropathic pain ... See more keywords
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Involvement of H19/miR‐326 axis in hepatocellular carcinoma development through modulating TWIST1

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27319

Abstract: Overexpression of long noncoding RNA (lncRNA) H19 has been observed in various cancers, which indicates that H19 exert important roles in the progression of carcinogenesis. MiR‐326 has been reported to play tumor suppressive roles in… read more here.

Keywords: hcc; mir 326; twist1; h19 mir ... See more keywords
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Twist1 as a target for prevention of cutaneous squamous cell carcinoma

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recommendations! Published in 2022 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23482

Abstract: Cutaneous squamous cell carcinoma (cSCC) represents an important clinical problem requiring novel approaches for both prevention and treatment. The transcription factor, Twist‐related protein 1 (Twist1), has been identified as having a key mechanistic role in… read more here.

Keywords: cell; cutaneous squamous; cscc; prevention ... See more keywords
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Linkage between EMT and stemness state through molecular association between TWIST1 and NY-ESO1 in esophageal squamous cell carcinoma.

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recommendations! Published in 2019 at "Biochimie"

DOI: 10.1016/j.biochi.2019.05.016

Abstract: Aberrant expression of cancer testis antigens (CTAs) is reported in tumors, especially those with stemness properties. A number of CTAs can induce epithelial mesenchymal transition (EMT) process and promote cancer stem cells (CSCs) characteristics. We… read more here.

Keywords: emt; twist1; twist1 eso1; expression ... See more keywords
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TGIF1-Twist1 axis in pancreatic ductal adenocarcinoma

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recommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"

DOI: 10.1016/j.csbj.2020.09.023

Abstract: TG-interacting factor 1 (TGIF1) exerts inhibitory effects on transforming growth factor-beta (TGF-β) signaling by suppressing Smad signaling pathway at multiple levels. TGIF1 activity is important for normal embryogenesis and organogenesis, yet its dysregulation can culminate… read more here.

Keywords: tgif1 twist1; tgif1; twist1; pancreatic ductal ... See more keywords
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Targeted in vivo epigenome editing in medaka fish

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recommendations! Published in 2017 at "Mechanisms of Development"

DOI: 10.1016/j.mod.2017.04.379

Abstract: between transcription factors and protein partners. For the BioID analysis, TWIST1 was fused to the BirA* biotin ligase that will biotinylate TWIST1 interacting proteins in the native condition and a cellular environment. The biotinylated proteins… read more here.

Keywords: medaka fish; vivo epigenome; targeted vivo; twist1 ... See more keywords
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Dual role of twist1 in cancer‐associated fibroblasts and tumor cells promoted epithelial‐mesenchymal transition of esophageal cancer

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recommendations! Published in 2019 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2019.01.002

Abstract: ABSTRACT Cancer‐associated fibroblasts (CAFs) play critical roles in tumor progression. However, the role and mechanism underlying CAFs in esophageal cancer (EC) remain unclear. In this study, primary CAFs and normal esophageal fibroblasts (NOFs) were isolated… read more here.

Keywords: cafs; twist1; associated fibroblasts; role ... See more keywords
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TWIST1 transcriptionally regulates glycolytic genes to promote the Warburg metabolism in pancreatic cancer.

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recommendations! Published in 2019 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2019.111713

Abstract: Reprogrammed glucose metabolism is essential for tumor initiation and development, especially for pancreatic ductal adenocarcinoma (PDAC). Most cancer cells rely on aerobic glycolysis, a phenomenon termed "the Warburg effect", to support uncontrolled proliferation and evade… read more here.

Keywords: pdac; metabolism; twist1; warburg metabolism ... See more keywords
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Twist1/Dnmt3a and miR186 establish a regulatory circuit that controls inflammation-associated prostate cancer progression

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recommendations! Published in 2017 at "Oncogenesis"

DOI: 10.1038/oncsis.2017.16

Abstract: Increasing evidences suggest that inflammatory microenvironment has a crucial role in prostate cancer (PCa) progression; however, the underlying mechanisms are unclear. Here, we used the inflammation-associated prostate cellular transformation model to screen out a crucial… read more here.

Keywords: mir186; inflammation associated; prostate cancer; twist1 ... See more keywords
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An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-59455-9

Abstract: Twist1 encodes a basic helix-loop-helix transcription factor (TF), which forms homodimer or heterodimer with other TFs, like E2A, to regulate target genes’ expression. Mutations in TWIST1 are associated with Saethre-Chotzen syndrome (SCS), a rare congenital… read more here.

Keywords: transcription; penetrance; twist1; dependent transcription ... See more keywords