Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators
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DOI: 10.1371/journal.pone.0214255
Abstract: Allosteric ligands bind to receptors at sites that are distinct from those endogenous agonists and orthosteric pharmacological agents interact with. Both an allosteric and orthosteric ligand bind simultaneously to the receptor to form a ternary… read more here.
Keywords: two allosteric; allosteric modulators; orthosteric tracer; binding orthosteric ... See more keywords