Two Flavoenzymes Convert Fungal Polyketide-Nonribosomal Peptide to cis-2-Butene-1,4-dial-Type Carcinogen via Olefin Dihydroxylation and C-C Bond Cleavage.
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DOI: 10.1021/jacs.5c11221
Abstract: Postmodification steps by multiple oxidation enzymes are an effective strategy for converting the polyketide-nonribosomal peptide (PK-NRP) core backbone to structurally distinctive natural products, where decoration steps occurring on conjugated polyenes (olefin ≥3) of the PK-NRP… read more here.
Keywords: polyketide nonribosomal; butene dial; type; two flavoenzymes ... See more keywords