RAG Deficiency: Two Genes, Many Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-018-0537-4
Abstract: PurposeTo review the clinical and laboratory spectrum of RAG gene defects in humans, and discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune dysregulation, and the current and perspective treatment modalities.MethodsLiterature review and analysis… read more here.
Keywords: treatment; rag deficiency; defects humans; gene defects ... See more keywords
By Staying Together, Two Genes Keep the Motor Running.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.01.005
Abstract: In this issue of Structure, Lynch et al. (2017) reveal that the interaction between two key proteins in the bacterial flagellar motor results in a shared structural domain. This unusual arrangement keeps the corresponding genes together… read more here.
Keywords: staying together; together two; genes keep; keep motor ... See more keywords
An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28799-8
Abstract: The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune and non-immune functions. Most studies however have focused on their role in shaping the HLA class I peptidome by trimming peptides… read more here.
Keywords: erap2; erap1 erap2; intergenic region; expression ... See more keywords
The tale of two genes: from next-generation sequencing to phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a004846
Abstract: An 18-yr-old man with a history of intellectual disability, craniofacial dysmorphism, seizure disorder, and obesity was identified to carry a de novo, pathogenic variant in ASXL1 (c.4198G>T; p.E1400X) associated with the diagnosis of Bohring–Opitz syndrome… read more here.
Keywords: tale two; genes next; next generation; generation sequencing ... See more keywords
A tale of two genes: a new connection between NIPBL and NPM1 in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.218867
Abstract: Acute myeloid leukemia (AML), the most common acute leukemia in adults, is defined by few somatic mutations in myeloid stem cells which drive abnormal proliferation and inhibit normal differentiation.[1][1] The overall survival rate of adults… read more here.
Keywords: genes new; tale two; myeloid leukemia; acute myeloid ... See more keywords
RNA Interference of Phenoloxidases of the Fall Armyworm, Spodoptera frugiperda, Enhance Susceptibility to Bacillus thuringiensis Protein Vip3Aa19
Sign Up to like & getrecommendations! Published in 2022 at "Insects"
DOI: 10.3390/insects13111041
Abstract: Simple Summary Phenoloxidase (PO) is an important part of the innate immune system of the fall armyworm, Spodoptera frugiperda. In this study, we screened two PO genes specifically expressed in the hemocyte transcriptome data of… read more here.
Keywords: spodoptera frugiperda; fall armyworm; frugiperda; two genes ... See more keywords
Genomic Biomarker Heterogeneities between SARS-CoV-2 and COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10101657
Abstract: Genes functionally associated with SARS-CoV-2 infection and genes functionally related to COVID-19 disease can be different, whose distinction will become the first essential step for successfully fighting against the COVID-19 pandemic. Unfortunately, this first step… read more here.
Keywords: genomic biomarker; disease; two genes; cov infection ... See more keywords