The link between microglia and the severity of COVID‐19: The “two‐hit” hypothesis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26984
Abstract: Highlights Neurological manifestations constitute a serious cause of severe coronavirus disease 2019 (COVID‐19). Microglial hyperactivation by the two‐hit process. Severe COVID‐19 patients carry pre‐activated microglia following a first immune challenge. Exaggerated response of sensitized microglia… read more here.
Keywords: covid two; microglia severity; link microglia; hit hypothesis ... See more keywords
Anhedonic-like behavior correlates with IFNγ serum levels in a two-hit model of depression
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112076
Abstract: Stress is implicated in the etiology of major depressive disorder (MDD) and leads to the activation of proinflammatory pathways, which are recognized to induce depressive symptoms. For instance, depression is commonly observed in patients with… read more here.
Keywords: hit model; model depression; like behavior; serum levels ... See more keywords
Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2021.2023740
Abstract: Abstract Acute lung injury (ALI) caused by acid aspiration often accompanies bacterial components leading to exaggerated inflammation and can result in acute respiratory distress syndrome (ARDS), but the underlying mechanisms behind such an exacerbation remain… read more here.
Keywords: inflammation; two hit; hit mediated; nlrp3 inflammasome ... See more keywords
A polygenic two-hit hypothesis for prostate cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djad001
Abstract: Prostate cancer is one of the most heritable cancers. Hundreds of germline polymorphisms have been linked to prostate cancer diagnosis and prognosis. Polygenic risk scores can predict genetic risk of a prostate cancer diagnosis. While… read more here.
Keywords: two hit; prostate cancer; polygenic two; risk ... See more keywords
Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01518
Abstract: IFN-γ release assays [e.g., QuantiFERON (QFT)] are widely used for diagnosis of Mycobacterium tuberculosis (Mtb) infection. T-cell responses against QFT antigens ESAT6 and CFP10 are highly Mtb specific but previous studies indicated suboptimal assay sensitivity.… read more here.
Keywords: stimulation; infection; tuberculosis patients; tuberculosis ... See more keywords