The tale of two talins – two isoforms to fine‐tune integrin signalling
Sign Up to like & getrecommendations! Published in 2018 at "Febs Letters"
DOI: 10.1002/1873-3468.13081
Abstract: Talins are cytoplasmic adapter proteins essential for integrin‐mediated cell adhesion to the extracellular matrix. Talins control the activation state of integrins, link integrins to cytoskeletal actin, recruit numerous signalling molecules that mediate integrin signalling and… read more here.
Keywords: talins two; two talins; tale two; two isoforms ... See more keywords
1 H, 15 N and 13 C chemical shift assignments of the N-terminal domain of the two isoforms of the human apolipoprotein E.
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecular NMR assignments"
DOI: 10.1007/s12104-022-10078-3
Abstract: Apolipoprotein E (ApoE) is one of the major lipid transporters in humans. It is also implicated in pathological conditions like Alzheimer's and cardiovascular diseases. The N-terminal domain of ApoE binds low-density lipoprotein receptors (LDLR) while… read more here.
Keywords: shift assignments; chemical shift; domain two; terminal domain ... See more keywords
Analysis of two transcript isoforms of vacuolar ATPase subunit H in mouse and zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.09.065
Abstract: ATP6V1H encodes the subunit H of vacuolar ATPase (V-ATPase) and has been recently proved to regulate osteoclast function. The alternative splicing of ATP6V1H gene results in two isoforms, and it is not clear whether and… read more here.
Keywords: atpase; two isoforms; analysis; vacuolar atpase ... See more keywords
Differential activation mechanisms of two isoforms of Gcr1 transcription factor generated from spliced and un-spliced transcripts in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1221
Abstract: Abstract Gcr1, an important transcription factor for glycolytic genes in Saccharomyces cerevisiae, was recently revealed to have two isoforms, Gcr1U and Gcr1S, produced from un-spliced and spliced transcripts, respectively. In this study, by generating strains… read more here.
Keywords: saccharomyces cerevisiae; two isoforms; spliced spliced; activation mechanisms ... See more keywords
Two isoforms of Arabidopsis protoporphyrinogen oxidase localize in different plastidal membranes
Sign Up to like & getrecommendations! Published in 2023 at "Plant Physiology"
DOI: 10.1093/plphys/kiad107
Abstract: Abstract All land plants encode 2 isoforms of protoporphyrinogen oxidase (PPO). While PPO1 is predominantly expressed in green tissues and its loss is seedling-lethal in Arabidopsis (Arabidopsis thaliana), the effects of PPO2 deficiency have not… read more here.
Keywords: protoporphyrinogen oxidase; two isoforms; isoforms arabidopsis; ppo2 ... See more keywords
A Tale of Two Isoforms: Calcium-Dependent Inhibition of SnRK2 by SnRK-Calcium-Binding Sensor
Sign Up to like & getrecommendations! Published in 2020 at "Plant Physiology"
DOI: 10.1104/pp.19.01554
Abstract: Reacting to the environment requires not only activating signaling cascades but also modulating the activity of individual components in a context- and time-dependent manner. For example, under nonstress conditions, protein phosphatases 2C (PP2C) keep the… read more here.
Keywords: calcium dependent; tale two; two isoforms; isoforms calcium ... See more keywords
The differential roles of the two NO-GC isoforms in adjusting airway reactivity
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Lung Cellular and Molecular Physiology"
DOI: 10.1152/ajplung.00404.2021
Abstract: The enzyme, nitric oxide-sensitive guanylyl cyclase (NO-GC) is activated by binding NO to its prosthetic heme group and catalyzes the formation of cGMP. The NO-GC is primarily known to mediate vascular smooth muscle relaxation in… read more here.
Keywords: two isoforms; physiology; gc1 kos; airway reactivity ... See more keywords
Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11060801
Abstract: Platelet-activating factor (PAF), a proinflammatory lipid mediator, plays a crucial role in the formation of the atherosclerotic plaque. Therefore, the inhibition of endothelium inflammation by nutraceuticals, such as PAF inhibitors, is a promising alternative for… read more here.
Keywords: paf metabolism; enriched yogurt; paf inhibitors; two isoforms ... See more keywords