Proteomic profiling of the hypothalamus in two mouse models of narcolepsy
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600478
Abstract: Narcolepsy is a disabling neurological disorder of sleepiness linked to the loss of neurons producing orexin neuropeptides in the hypothalamus. Two well‐characterized phenotypic mouse models of narcolepsy, loss‐of‐function (orexin‐knockout), and progressive loss of orexin (orexin/ataxin‐3)… read more here.
Keywords: models narcolepsy; orexin; mouse models; hypothalamus two ... See more keywords
Variable behavior and repeated learning in two mouse strains: Developmental and genetic contributions
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Processes"
DOI: 10.1016/j.beproc.2018.06.007
Abstract: Behavioral inflexibility is often assessed using reversal learning tasks, which require a relatively low degree of response variability. No studies have assessed sensitivity to reinforcement contingencies that specifically select highly variable response patterns in mice,… read more here.
Keywords: variability; mouse strains; reinforcement; mice ... See more keywords
Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.632843
Abstract: Alzheimer's disease (AD), one of the most common neurodegenerative diseases, has no effective treatment. We studied the potential effects of tetramethylpyrazine (TMP), an alkaloid in the rhizome of Ligusticum chuanxiong Hort. used in Traditional Chinese… read more here.
Keywords: mouse models; alzheimer disease; mice; tmp ... See more keywords