Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction
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DOI: 10.1111/jth.14716
Abstract: Plasminogen activator inhibitor‐1 (PAI‐1), a key inhibitor of plasminogen activators (PAs) tissue‐type PA (tPA) and urokinase‐type PA (uPA) plays a crucial role in many (patho)physiological processes (e.g., cardiovascular disease, tissue fibrosis) as well as in… read more here.
Keywords: two nanobodies; plasminogen; mechanism two; molecular mechanism ... See more keywords