Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory
Sign Up to like & getrecommendations! Published in 2020 at "Behavior Genetics"
DOI: 10.1007/s10519-020-10011-1
Abstract: Two-pore channels (TPCs) constitute a small family of cation channels that are localized in membranes of endosomal and lysosomal compartments. Although their roles for vesicular fusion and endolysosomal trafficking have been investigated, our knowledge on… read more here.
Keywords: tpc1; tpc1 mice; learning memory; genetic inactivation ... See more keywords
Two-pore channels as master regulators of membrane trafficking and endocytic well-being
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Physiology"
DOI: 10.1016/j.cophys.2020.08.002
Abstract: Two-pore channels (TPCs) are a ubiquitous class of Ca2+- and Na+-permeable ion channels expressed within the endo-lysosomal system. They have emerged as central regulators of a wide array of physiological processes intimately linked to information… read more here.
Keywords: regulators membrane; pore channels; channels master; master regulators ... See more keywords
Regulation of two-pore-domain potassium TREK channels and their involvement in pain perception and migraine
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136494
Abstract: The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that transduce noxious stimuli into pain. Among these ion channel, TREK1, TREK2 and TRAAK… read more here.
Keywords: pain; two pore; pore domain; domain potassium ... See more keywords
Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24735-z
Abstract: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-mobilizing second messenger which uniquely mobilizes Ca2+ from acidic endolysosomal organelles. However, the molecular identity of the NAADP receptor remains unknown. Given the necessity of the… read more here.
Keywords: protein; two pore; naadp receptor; receptor ... See more keywords
The human two-pore channel 1 is modulated by cytosolic and luminal calcium
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43900
Abstract: Two-pore channels (TPC) are intracellular endo-lysosomal proteins with only recently emerging roles in organellar signalling and involvement in severe human diseases. Here, we investigated the functional properties of human TPC1 expressed in TPC-free vacuoles from… read more here.
Keywords: pore channel; two pore; human two; ca2 ... See more keywords
Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46085
Abstract: Two-pore domain (K2P) potassium channels perform essential roles in neuronal function. These channels produce background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability. 15 different K2P channels… read more here.
Keywords: potassium; k2p; k2p channels; two pore ... See more keywords
Two-pore channels: going with the flows
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220229
Abstract: In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P2, TPCs are an integral part of… read more here.
Keywords: going flows; channels going; two pore; pore channels ... See more keywords
Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209569120
Abstract: Two-pore channels (TPCs) are activated by phosphatidylinositol bisphosphate (PIP2) binding to domain I and/or by voltage sensing in domain II (DII). Little is known about how these two stimuli are integrated, and how each TPC… read more here.
Keywords: pore channels; voltage; domain; two pore ... See more keywords
Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions
Sign Up to like & getrecommendations! Published in 2017 at "Channels"
DOI: 10.1080/19336950.2016.1213929
Abstract: ABSTRACT Two-pore channels (TPC1-3) comprise a subfamily of the eukaryotic voltage-gated ion channels (VGICs) superfamily that are mainly expressed in acidic stores in plants and animals. TPCS are widespread across the animal kingdom, with primates,… read more here.
Keywords: ion channels; pore channels; gated ion; two pore ... See more keywords
Two‐pore channel protein TPC1 is a determining factor for the adaptation of proximal tubular phosphate handling
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13914
Abstract: Two‐pore channels (TPCs) constitute a small family of cation channels expressed in endo‐lysosomal compartments. TPCs have been characterized as critical elements controlling Ca2+‐mediated vesicular membrane fusion and thereby regulating endo‐lysosomal vesicle trafficking. Exo‐ and endocytotic… read more here.
Keywords: channel protein; tpc1 determining; two pore; protein tpc1 ... See more keywords
NAADP‐induced intracellular calcium ion is mediated by the TPCs (two‐pore channels) in hypoxia‐induced pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16783
Abstract: Pulmonary arterial hypertension (PAH) is a form of obstructive vascular disease. Chronic hypoxic exposure leads to excessive proliferation of pulmonary arterial smooth muscle cells and pulmonary arterial endothelial cells. This condition can potentially be aggravated… read more here.
Keywords: tpc1; arterial hypertension; naadp induced; pulmonary arterial ... See more keywords