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   Articles with "two pore" as a keyword



Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory

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recommendations! Published in 2020 at "Behavior Genetics"

DOI: 10.1007/s10519-020-10011-1

Abstract: Two-pore channels (TPCs) constitute a small family of cation channels that are localized in membranes of endosomal and lysosomal compartments. Although their roles for vesicular fusion and endolysosomal trafficking have been investigated, our knowledge on… read more here.

Keywords: tpc1; tpc1 mice; learning memory; genetic inactivation ... See more keywords
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Two-pore channels as master regulators of membrane trafficking and endocytic well-being

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recommendations! Published in 2020 at "Current Opinion in Physiology"

DOI: 10.1016/j.cophys.2020.08.002

Abstract: Two-pore channels (TPCs) are a ubiquitous class of Ca2+- and Na+-permeable ion channels expressed within the endo-lysosomal system. They have emerged as central regulators of a wide array of physiological processes intimately linked to information… read more here.

Keywords: regulators membrane; pore channels; channels master; master regulators ... See more keywords

Regulation of two-pore-domain potassium TREK channels and their involvement in pain perception and migraine

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recommendations! Published in 2022 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2022.136494

Abstract: The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that transduce noxious stimuli into pain. Among these ion channel, TREK1, TREK2 and TRAAK… read more here.

Keywords: pain; two pore; pore domain; domain potassium ... See more keywords
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Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-24735-z

Abstract: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-mobilizing second messenger which uniquely mobilizes Ca2+ from acidic endolysosomal organelles. However, the molecular identity of the NAADP receptor remains unknown. Given the necessity of the… read more here.

Keywords: protein; two pore; naadp receptor; receptor ... See more keywords

Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-47208-5

Abstract: TRAAK, TREK-1, and TREK-2 are mechanosensitive two-pore domain K+ (K2P) channels that contribute to action potential propagation, sensory transduction, and muscle contraction. While structural and functional studies have led to models that explain their mechanosensitivity,… read more here.

Keywords: traak trek; two pore; trek; trek trek ... See more keywords

The human two-pore channel 1 is modulated by cytosolic and luminal calcium

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep43900

Abstract: Two-pore channels (TPC) are intracellular endo-lysosomal proteins with only recently emerging roles in organellar signalling and involvement in severe human diseases. Here, we investigated the functional properties of human TPC1 expressed in TPC-free vacuoles from… read more here.

Keywords: pore channel; two pore; human two; ca2 ... See more keywords

Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep46085

Abstract: Two-pore domain (K2P) potassium channels perform essential roles in neuronal function. These channels produce background leak type potassium currents that act to regulate resting membrane potential and levels of cellular excitability. 15 different K2P channels… read more here.

Keywords: potassium; k2p; k2p channels; two pore ... See more keywords

Two-pore channels: going with the flows

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recommendations! Published in 2022 at "Biochemical Society Transactions"

DOI: 10.1042/bst20220229

Abstract: In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P2, TPCs are an integral part of… read more here.

Keywords: going flows; channels going; two pore; pore channels ... See more keywords

Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels.

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2209569120

Abstract: Two-pore channels (TPCs) are activated by phosphatidylinositol bisphosphate (PIP2) binding to domain I and/or by voltage sensing in domain II (DII). Little is known about how these two stimuli are integrated, and how each TPC… read more here.

Keywords: pore channels; voltage; domain; two pore ... See more keywords
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Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions

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recommendations! Published in 2017 at "Channels"

DOI: 10.1080/19336950.2016.1213929

Abstract: ABSTRACT Two-pore channels (TPC1-3) comprise a subfamily of the eukaryotic voltage-gated ion channels (VGICs) superfamily that are mainly expressed in acidic stores in plants and animals. TPCS are widespread across the animal kingdom, with primates,… read more here.

Keywords: ion channels; pore channels; gated ion; two pore ... See more keywords

Constitutive sodium permeability in a C. elegans two-pore domain potassium channel

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1101/2024.01.22.576648

Abstract: Two-pore domain potassium (K2P) channels play a central role in modulating cellular excitability and neuronal function. The unique structure of the selectivity filter in K2P and other potassium channels determines their ability to allow the… read more here.

Keywords: two pore; sodium; k2p; selectivity filter ... See more keywords